Translation. Region: Russian Federation –
Source: Peter the Great St Petersburg Polytechnic University – Peter the Great St Petersburg Polytechnic University –
Researchers from Peter the Great St. Petersburg Polytechnic University have published the results of a study of a potential pharmacological agent for the treatment of Alzheimer’s disease. Scientific Reports, the fifth most popular scientific journal in the world, has published an article by a team of scientists from the Polytechnic University and the Russian-Armenian University, dedicated to the study of Alzheimer’s disease.
This disease is characterized by progressive memory loss and requires new approaches to create effective drug therapy. The transmission of nerve impulses from one cell to another occurs in synapses. Synapse loss is an important indicator of cognitive dysfunction in patients with Alzheimer’s disease. Restoring or limiting synapse loss is a promising strategy for pharmacotherapy of the disease.
Derivatives of such a substance as piperazine are used for the drug treatment of various diseases, including a number of diseases of the central nervous system. Scientists have synthesized a new piperazine derivative cmp2, which has synaptoprotective properties. In vivo research has shown that cmp2 (10 mg/kg intraperitoneally) eliminates the deficit of synaptic plasticity in mice and it can be argued that cmp2 is a new promising compound for drug development. The mechanism of action of cmp2 is based on selective stimulation of the TRPC6 channel, and it is expected that activation of this channel will compensate for synaptic insufficiency in hippocampal neurons.
This work was financially supported by the grant of the Russian Science Foundation No. 20-75-10026 and the Ministry of Education and Science of Russia within the framework of the state assignment on the topic “Scientific, methodological and resource support for the implementation of measures to improve the efficiency of the Russian-Armenian (Slavic) and Belarusian-Russian universities in training personnel for the digital economy, including using modern distance technologies” (Additional agreement dated 05/15/2024
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