Translation. Region: Russian Federal
Source: People’s Republic of China in Russian –
Source: People’s Republic of China – State Council News
BEIJING, June 20 (Xinhua) — A team of Chinese researchers has developed a hydrogel cocktail that can promote the regeneration of the neurovascular system and repair of damaged brain tissue, providing an important theoretical basis and new strategies for cell replacement therapy for cerebral cortex injury.
Transplantation of human neural progenitor cells has great potential in the treatment of traumatic brain injury. However, it faces problems such as low cell survival, unclear lineage, and low efficiency of functional integration.
Researchers from the Guangzhou Institute of Biomedicine and Health Sciences, Chinese Academy of Sciences, have developed a new cocktail hydrogel that has a three-dimensional framework structure with biomimetic properties.
According to a paper published recently in the Journal of Advanced Research, the material can mimic the biochemical and mechanical environment of the natural extracellular matrix, significantly improving the adhesion, survival, and lineage-specific differentiation of human neural progenitor cells.
Biomimetic structures created from hydrogel, interacting with a bioactive microenvironment, provide stable signals of neurogenic induction, imitating the characteristics of brain tissue, thereby effectively stimulating the transformation of human neural progenitor cells into functional interneurons – a key type of neurons that ensures advanced human activity.
The study also showed that the hydrogel could help restore the microstructure of the neurovascular node, significantly improve the local immune and metabolic microenvironment at the injury site, and promote the engraftment of human neural progenitor cells and their transformation into cortical interneurons, thus changing the structure of damaged brain tissue and partially restoring nerve conduction function. -0-