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Category: Health

  • MIL-OSI USA: Infusion Pump Recall: Zyno Medical Removes Z-800, Z-800F, Z-800W, and Z800WF Infusion Pumps due to an Air-in-Line Software Defect That May Allow Larger than Expected Air Bubbles to Enter Patients

    Source: US Department of Health and Human Services – 3

    This recall involves removing certain devices from where they are used or sold. The FDA has identified this recall as the most serious type. This device may cause serious injury or death if you continue to use it. 

    Affected Product 

    Pump Model

    Unique Device Identifier (UDI-DI)  

    Software Revision

    Z-800

    00814371020006 

    6.1.01 and 6.1.07z

    Z-800W

    00814371020020

    3.1.32 and 3.1.64z

    Z-800F

    00814371020013  

    4.1.02 and 4.1.08z

    Z-800WF

    00814371020037

    5.1.01 and 5.1.08z

    What to Do  

    • Do not use affected infusion pumps. 

    On September 13, 2024, Zyno Medical LLC sent all affected customers an Urgent Medical Device Correction letter recommending the following actions: 

    • Stop using affected devices.
    • Follow instructions to return these devices for software update.
    • Complete the Zyno Medical Z-800, Z-800F, Z-800W, and Z-800WF Infusion Pump – Air-in-Line Software Issue – Response Verification Form which includes the following activities: 
      • Checking inventory for affected products.
      • Verifying serial numbers.
      • Confirming product location.
      • Reporting any transferred product.
      • Signing and dating the completed form. 
    • Make sure this notice reaches everyone who needs to be informed, including those at other locations if the devices have been transferred. 

    A representative from Zyno Medical’s partner company, Intuvie LLC, will contact customers to coordinate instructions for exchanging devices. 

    Reason for Recall   

    Zyno Medical is recalling certain Zyno Medical Z-800, Z-800F, Z-800W, and Z-800WF infusion pumps due to a defect in the air-in-line software algorithm that may allow a 1.0 mL air bubble to be passed on to a patient. 
     
    The use of affected product may cause serious adverse health consequences, including air entering the blood vessels (vascular air embolism), fast and irregular heartbeat (tachyarrhythmia), heart attack (myocardial infarction), stroke, seizure, and death. 
      
    There have been two reported injuries. There have been no reports of death. 

    Device Use 

    Zyno Medical Z800 Infusion Systems are intended to provide infusion through the blood vessels (intravenous) of nutrition or essential (parenteral) fluids, blood, and blood products under the direction or supervision of a health care professional.   

    Contact Information  

    Customers in the U.S. with questions about this recall should contact their Zyno Medical local business partner or email feedback@intuvie.com. 

    Additional FDA Resources (listed in order of most to least recent):  

    Unique Device Identifier (UDI) 

    The unique device identifier (UDI) helps identify individual medical devices sold in the United States from manufacturing through distribution to patient use. The UDI allows for more accurate reporting, reviewing, and analyzing of adverse event reports so that devices can be identified, and problems potentially corrected more quickly. 

    How do I report a problem? 

    Health care professionals and consumers may report adverse reactions or quality problems they experienced using these devices to MedWatch: The FDA Safety Information and Adverse Event Reporting Program. 

    MIL OSI USA News –

  • MIL-OSI Global: Music and dementia: researchers are still making discoveries about how songs can help sufferers

    Source: The Conversation – UK – By Rebecca Atkinson, Researcher in Music Therapy, Anglia Ruskin University

    Numerous studies have shown music therapy has many benefits for dementia patients. Unai Huizi Photography/ Shutterstock

    Music is woven into the fabric of our everyday lives. Whether it’s lifting our spirits, pushing us to run faster or soothing us to sleep, we can all recognise its power. So it’s no wonder it is increasingly being used in medical treatment.

    As well as proving very useful in cancer treatment, managing chronic pain and even helping the brain recover after a stroke, researchers have also been making great strides in using music to help patients with dementia.

    It reduces patients’ anxiety and depression, and improves wellbeing both for them and their carers by enhancing everyone’s ability to adapt and cope with adversity or stress.

    Music therapy in the form of playing, singing or listening to music can also have a positive effect on cognitive function – particularly for older adults either with dementia or memory issues.

    So why does music appear to have such a powerful effect for people with dementia?

    Music and the brain

    About a decade ago, researchers discovered that when people listened to music, multiple areas of the brain were involved in processing it. These included the limbic (which processes emotions and memory), cognitive (involved with perception, learning and reaction) and motor areas (responsible for voluntary movement). This challenged preconceptions that music was processed more narrowly in the brain – and helped explain why it has such a unique neurological impact.

    Not only that, research has shown that music might help regenerate the brain and its connections. Many causes of dementia centre around cell death in the brain, raising the possibility that music could help people with dementia by mending or strengthening damaged neural connections and cells.

    Many brain areas are activated when we listen to music.
    Toa55/ Shutterstock

    It’s not just any music that has a regenerative effect on the brain, though. Familiar and favourite music has been shown to have the biggest impact on the way we feel, and is closely linked with memory and emotions. This is because listening to our favourite songs releases feel-good hormones that give us a sense of pleasure. Curated music playlists of favourite music could be the key in helping us deal with the stress of everyday life.

    This is relevant to Alzheimer’s and other forms of dementia because researchers have discovered that parts of the brain linked with musical memories are less affected by these conditions than other areas of the brain. This explains why memories and experiences that are linked to favourite music are often preserved for people with such conditions.

    Listening to music can also help manage their experiences of distress, agitation and “sundowning” – where a person is more confused in the afternoon and evening.

    In a small study conducted by us and our colleagues at the Cambridge Institute for Music Therapy Research, we showed just how great of an effect listening to music can have for people with dementia. We found that when people with dementia repeatedly listened to their favourite music, their heart rate and movements changed in direct response.

    This showed that people’s physical responses were affected by musical features like rhythm and arrangement. Their heart rate also changed when they sang along to music, or when they began reminiscing about old memories or stories while listening to a song or thinking about the music. These changes are important because they show how music affects movement, emotions and memory recall.

    Studies have also shown that during and after listening to music, people with dementia experienced less agitation, aggression and anxiety, and their general mood was improved. They even needed less medication when they had regular music sessions.



    Read more:
    Why researchers are turning to music as a possible treatment for stroke, brain injuries and even Parkinson’s

    Other researchers have even begun testing the effects of music training programmes to support cognition for people with dementia. Results have been promising so far – with adults in the study showing improved executive functioning (problem solving, emotion regulation and attention) compared to those who took part in just physical exercise.

    So, music is likely to continue to be a useful medical treatment for people with dementia. But based on what we know so far, it’s important that it comes from the patient’s own music collection – and is used alongside other management techniques such as using drugs that can slow the progression of dementia or help manage symptoms to support self-care and wellbeing.

    Dr. Rebecca Atkinson is affliated with Chiltern Music Therapy, non-profit organisation.

    Ming-Hung Hsu receives funding from the National Institute for Health and Care Research and Innovate UK.

    – ref. Music and dementia: researchers are still making discoveries about how songs can help sufferers – https://theconversation.com/music-and-dementia-researchers-are-still-making-discoveries-about-how-songs-can-help-sufferers-239446

    MIL OSI – Global Reports –

  • MIL-OSI: Avetta and Energy Worldnet Forge Partnership to Transform Operator Qualification Compliance Management in the Oil and Gas Industry

    Source: GlobeNewswire (MIL-OSI)

    LEHI, Utah and HOUSTON, Oct. 15, 2024 (GLOBE NEWSWIRE) — Avetta®, the leading provider of supply chain risk management (SCRM) software, announced a strategic partnership with Energy Worldnet (EWN), an industry benchmark in training and compliance solutions for the energy sector. This collaboration will combine EWN’s Operator Qualification (OQ) management features and the Avetta One platform, delivering a streamlined solution for midstream operators to enhance worker safety and meet regulatory OQ compliance requirements.

    Managing contractor qualifications can be a significant administrative burden, particularly for clients under Pipeline and Hazardous Materials Safety Administration (PHMSA) regulations. The oil and gas industry has long awaited a solution to eliminate data consistency issues between OQ providers and compliance software, which often slows a client’s ability to respond to PHMSA audits. This newly announced partnership addresses this need by providing a seamless approach to managing contractor OQ compliance alongside existing prequalification, business, financial, and cyber risk assessments, ensuring adherence and oversight of critical safety standards in pipeline operations.

    “Integrating EWN’s OQ data with Avetta One Worker Management equips pipeline operators with a single platform to oversee both safety and OQ requirements efficiently,” said Taylor Allis, CPO of Avetta. “Pipeline operator qualification gets complicated with changing requirements, but EWN and Avetta offer a streamlined solution that improves training, transparency, and traceability, simplifying operations and PHMSA audits.”

    “We’re excited to partner with Avetta to enhance compliance in the energy sector,” said Coleman Sterling, EWN’s CEO. “This integration aligns with EWN’s commitment to delivering cutting-edge tools that streamline OQ processes, ensuring safety and regulatory compliance. Together, we’re driving operational excellence across the industry.”

    Additional benefits include improved compliance tracking for regulatory audits, data synchronization to ensure contractor OQ compliance information is current and accurate, and a comprehensive view of contractor compliance, workforce safety, and OQ compliance for clients managing active pipeline operations. Data will also be available on Avetta’s Mobile Solution, allowing contractors to view compliance information onsite.

    “We are thrilled about Avetta’s partnership with EWN, as it opens up new pathways for streamlined OQ solutions, empowering teams to ensure compliance and boost operational efficiency,” said Sean Kelly, Director of Environmental, Health, Safety and Compliance at Producers Midstream. “With the addition of the Safety Maturity Index (SMI), an even more robust and streamlined contractor/supplier solution, we’re fueling a future where safety and excellence go hand in hand.”

    For more information, please visit https://www.avetta.com/operator-qualifications.

    About Avetta
    The Avetta SaaS platform helps clients manage supply chain risk and their suppliers to become more qualified for jobs. We offer the world’s largest supply chain risk management network for hiring clients in our network to manage supplier safety, sustainability, worker competency, and performance. We perform contractor prequalification and worker competency management across major industries all over the globe, including construction, energy, facilities, high-tech, manufacturing, mining, and telecom.

    About Energy Worldnet
    Energy Worldnet, Inc. is a leading provider of training and compliance solutions for the energy industry. EWN’s comprehensive training solutions include online and classroom training, competency assessments, and compliance management tools. Learn more about EWN’s comprehensive offerings at https://www.ewn.com.

    Media Contact:
    avetta@hoffman.com

    The MIL Network –

  • MIL-OSI: Empathy Launches LifeVault, Bringing Trusted and Personalized Legacy Planning to Life Insurance Clients Across the U.S.

    Source: GlobeNewswire (MIL-OSI)

    NEW YORK, Oct. 15, 2024 (GLOBE NEWSWIRE) — Empathy, the world leader in helping families deal with loss, has announced the launch of its newest product offering, LifeVault™ which makes it easier than ever for Americans to build comprehensive legacy plans. LifeVault represents the next phase of Empathy’s mission to change the way Americans manage the loss of a loved one by making personalized, holistic legacy planning and support more accessible.

    “At Empathy, we support families during some of life’s most challenging moments, starting with our first-in-class product for support after the loss of a loved one, and now with LifeVault which puts the focus on planning ahead,” said Empathy co-founder and CEO Ron Gura. “LifeVault is the next phase of Empathy’s mission — making personalized, holistic legacy planning and support possible for even more families.”

    Most families perceive estate planning as complex, time-consuming, and costly. For these reasons, 67 percent of Americans have no estate plan in place—a number that disproportionately affects middle- and lower-income families.

    With LifeVault, Empathy further establishes its deep understanding of what families need to handle loss in America, leveraging corporate partnerships to support millions of families in their time of need. Empathy’s LifeVault is a white-labeled solution that increases access to estate planning services via thoughtful tailored integrations with trusted life insurance carriers and agents, empowering families with the legacy planning tools they need to make informed choices and move forward in confidence following the loss of a loved one.

    LifeVault will be available to families via financial institutions, empowering them to take control of their legacy with tools and guidance to create more comprehensive roadmaps. By working with trusted and enduring financial institutions, individuals can ensure that their families will be taken care of both financially and administratively––a streamlined experience that will pay dividends to countless families in the years to come as they cope with a new reality following loss.

    Clients will be able to revisit their plans and choices to make updates to a variety of integral legacy planning documents, including: 

    1. Last Will & Testament
    2. Health Care Directive
    3. Power of Attorney
    4. Funeral Directive

    New York Life, the largest mutual life insurance company in the United States, served as an initial design partner with Empathy on LifeVault. The company was the first life insurance carrier to leverage Empathy’s loss support for bereaved families and now is the first insurer to introduce the legacy planning offering.

    “Our ongoing partnership with Empathy well-represents New York Life’s continued commitment to delivering exceptional client and agent experiences through innovation,” said Regina Warga, head of client experience, New York Life. “This includes empowering our agents to deliver further value to our clients and their loved ones through new technologies like Empathy’s latest offering that are designed to strengthen relationships and support families as they build legacies and secure financial futures.”

    With a deep commitment to helping families work through life’s most difficult moments, Empathy is redefining the way that we plan for and deal with loss. Learn more about how Empathy is changing the way the world deals with loss at https://www.empathy.com/.

    ABOUT EMPATHY

    Empathy is a technology company transforming the way the world prepares for and manages the loss of a loved one. With $90 million in total funding from leading tech investors and the largest global insurance carriers, Empathy is at the forefront of the emerging compassionate economy, setting the new standard in family care and modern employment benefits. Founded in 2020 by Ron Gura and Yonatan Bergman, Empathy offers a full range of assistance to those facing grief, estate planning and settlement, probate and more through life insurance benefits or via bereavement leave through an employer. By partnering with Fortune 500 companies and leading insurance carriers, Empathy currently offers services to 40 million covered individuals across the U.S. at no cost to families. Empathy uses its award-winning app and Care Team to carefully assess needs and next steps and complements experiences through time-saving and tech-enabled tools to effectively provide personalized plans, automated workflows and care resources, including an extensive library of articles, guides and meditation tools to support them through their grieving process. With accolades from Apple, Google Play, CB Insights and Fast Company, Empathy is the fastest-growing benefit for insurance carriers and employers alike. Learn more about Empathy at http://www.empathy.com.

    Contact:
    press@empathy.com

    The MIL Network –

  • MIL-OSI United Kingdom: River of Light Shines Bright For All

    Source: City of Liverpool

    With just over a week to go until River of Light returns, Liverpool City Council unveils plans to make the popular event even more accessible, inclusive and engaging.

    Building on the success of last year, the FREE event will once again offer Quiet Hour sessions to accommodate visitors with additional sensory needs. These special sessions will run from 4-5pm on Sunday 27 and Monday 28 October, and the same times on Sunday 3 and Monday 4 November. During these hours, the 12 featured installations will have reduced soundscapes or will operate entirely without sound. Where possible, lighting will also be softened, creating a calmer environment for those with sensory sensitivities.

    This year’s light festival runs from Friday 25 October to Tuesday 5 November, taking place at the same time as Diwali – the Hindu festival of lights. To mark the cultural celebration, on Friday 1 November visitors can enjoy a programme curated by Indian arts organisation, MILAP, featuring performances by the popular Bombay Baja Brass Band and Piano with Bhav between 5-8pm– all taking place near the Rangoli Mirrored Cosmos installation by award-winning artist MURUGIAH.

    The young people’s engagement programme, developed by the City Council’s Culture Liverpool team returns this year and connects young people with three of the event’s featured artists, offering creative, hands-on workshops that encourage artistic expression and learning.

    • Families attending Granby Children’s Centre and Family Hub will have the opportunity to work with MURUGIAH, who will guide participants through the creation of Mandalas – repetitive geometric designs which represent harmony and balance.
    • Students at St John Bosco Arts College will have a masterclass in sign-making from locally commissioned artist Liz Harry, learning the art of communication through visual design.
    • Pupils at Holy Family Catholic Primary School will collaborate with Rachel Darnell and Jorge Fernandez from Australia’s Amigo & Amigo, designing and crafting their very own gnomes – inspired by their 2024 River of Light installation, No Place Like Gnome.
    • Working with the City Council’s Children and Young People’s team, there will also be a guided tour for young people who are part of the Positive Pathways scheme, aimed at those who could otherwise be at risk of being involved with anti-social behaviour.

    The theme for this year’s outdoor trail and the engagement programme is Play, tying into Liverpool’s ongoing pledge to become a recognised UNICEF UK Child Friendly City. The initiative highlights the importance of children’s rights to play, recreation, rest, and leisure, as outlined in the United Nations Convention on the Rights of the Child. #ChildFriendlyLpool

    To get the latest information visit http://www.visitliverpool.com/riveroflight or follow @visitliverpool (X, Facebook and TikTok) or @visitliverpool_ (Instagram).

    River of Light will be part-funded by the UK Government through the UK Shared Prosperity Fund with the Liverpool City Region Combined Authority as the lead authority. Avanti is the official travel partner for the event.

    Liverpool City Council’s Cabinet Member for Culture, Health and Wellbeing, Councillor Harry Doyle, said:

    “We’re thrilled to bring back the quiet hours this year after receiving such positive feedback from visitors in 2023. It brought in a new audience who hadn’t experienced the trail previously, and thanks to some adaptations to the light and sound, they felt part of this massively popular event. 

    “It’s also great to see the return of the workshops – they’re so unique, and the youngsters and the artists always get a huge amount out of the sessions. Encouraging children to express themselves through art and creativity is an incredibly powerful tool that will hopefully inspire future artists.

    “Celebrating Diwali as part of the River of Light is a fantastic way to embrace cultural diversity and unity and we’re delighted to be working with Milap on this. Bringing together communities through art, music, and tradition, fostering a real sense of belonging and is certain to be a highlight of the festival.”

    Alok Nayak, Milap’s CEO and Artistic Director, said:

    “We are excited to be part of River of Light 2024, an event that unites art, culture, and community. At Milap, we believe in the power of the arts to inspire, educate, and bring people together.

    “This is a fantastic opportunity to showcase the richness of Indian arts, while contributing to Liverpool’s dynamic cultural landscape. Diwali, the festival of light, is beautifully reflected in Liverpool’s own light festival, making our collaboration with Culture Liverpool to bring MURUGIAH’s ‘Rangoli Mirrored Cosmos’ to the city even more meaningful.

    “Rangoli patterns are recreated in homes, in designs and works of art worldwide, and this concept will come to life on Liverpool’s waterfront through MURUGIAHS’s unique reimagining. We’re eager to share this experience with the public and celebrate the positive impact of creativity and diversity!”

    Denise Wright, Liverpool City Council’s Family Learning Co-ordinator for Children Centre’s and Family Hubs, said:
    “This is a wonderful opportunity for families with young children to work with a world-renowned artist at one of our main Family Hub sites. The River of Light’s theme of PLAY this year is great for engaging families in rich creative and cultural experiences in their own communities and for connecting families to a major interactive and cultural event in the city.”

    MIL OSI United Kingdom –

  • MIL-OSI USA: New Oat Ready for Active Duty Against Crown Rust Disease

    Source: US Agriculture Research Service

    New Oat Ready for Active Duty Against Crown Rust Disease

    Contact: Jan Suszkiw
    Email: Jan.Suszkiw@usda.gov

    October 15,2024

    A team of Agricultural Research Service (ARS) and university scientists has released two new oat germplasm lines to shore up the cereal crop’s defenses against its most devastating fungal disease, known as “crown rust.”

    The team specifically created the oat lines so that they can be crossed with elite commercial varieties to fortify them with new genetic sources of resistance to crown rust, which is caused by the fungus Puccinia coronata f. sp. avenae. Crown rust is a plague of oat worldwide and can inflict grain yield losses of up to 50 percent in unprotected crops.

    The team announced its development of the resistant oat germplasm lines—dubbed CDL-111 and CDL-167—in the May 2024 issue of the Journal of Plant Registration, culminating more than 25 years of germplasm screening, plant genetic mapping, selective breeding and evaluation in greenhouse and field trials.

    “Currently, the majority of the oat varieties with rust resistance carry a gene or two for resistance (often referred to as seedling resistance) to a specific isolate of crown rust,” said Shahryar Kianian, a co-author on the journal paper and research leader of the ARS Cereal Diseases Laboratory in St. Paul, Minnesota.

    However, the crown rust fungus is a genetically diverse pathogen and highly adept at evolving into virulent new forms, called races. This can happen so quickly that the average productive life of an oat variety with seedling resistance is between three and five years, necessitating the use of chemical fungicides in conventional production systems.

    Unchecked, the fungus infects the lower leaves and sometimes the sheafs of vulnerable oat plants, forming round- to oval-shaped pustules packed with masses of orangish spores that can be carried away by wind or rain. Damage to leaves can diminish photosynthesis and disrupt the movement of sugars from the leaves to developing grain, shriveling it and reducing feed value.

    . ARS and university scientists have released two new lines of oat to better fortify this important grain crop’s defense against the fungus that causes “crown rust” disease.

    To even the odds in the oat plant’s favor, the team resorted to a plant breeding strategy called “gene stacking” (or “pyramiding”). A key part of that strategy involved making a series of crosses between a cultivated oat variety and wild relatives, one known as lopsided oat, which carry genes for “adult plant resistance.”

    “Adult plant resistance, sometimes referred to as ‘slow rusting,’ provides the oat plant some immunity—but not complete immunity,” Kianian said. “In this case, the selection pressure on the pathogen to change is reduced, and the plant is not damaged much so that it can still produce and yield grain for the growers.”

    All told, the team stacked offspring plants derived from crosses with three genes for adult plant resistance to crown rust. They then subjected the offspring plants to a trial by fire, of sorts, starting in 2020. In essence, this involved growing them in nursery plots of common buckthorn, a secondary host for crown rust and known source of outbreaks. In the plots, under intense pressure from the disease, two lines of offspring plants consistently fared better than the others, namely, CDL-111 and CDL-167.

    The sturdy oat lines have since been propagated for their seed, which is available for use in variety development programs under a material transfer agreement with ARS, Kianian said. This is to ensure the effectiveness of the gene-stacking strategy if the oat lines are crossed with commercial varieties—regardless of whether they already possess seedling resistance to crown rust.

    By adhering to this requirement, plant breeders can arm elite oat varieties adapted to particular production regions with a one-two punch against the crown rust fungus—a “jab” via seedling resistance and a “right hook” with adult plant resistance.

    “For this, we are also providing molecular markers linked to the three genes that can be used in selecting the lines that carry them,” added Kianian, who collaborated with Eric Nazareno and Kevin Smith—both with the University of Minnesota—Melanie Caffe (South Dakota State University), Roger Caspers (ARS), Howard Rines (ARS, deceased) and Marty Carson (ARS, deceased). Carson started some of the oat work 20 years ago, continuing much of it after retirement, Kianian noted.

    The Agricultural Research Service is the U.S. Department of Agriculture’s chief scientific in-house research agency. Daily, ARS focuses on solutions to agricultural problems affecting America. Each dollar invested in U.S. agricultural research results in $20 of economic impact.

    MIL OSI USA News –

  • MIL-OSI USA: Alzheimer’s disease may damage the brain in two phases

    Source: US Department of Health and Human Services – 2

    News Release

    Tuesday, October 15, 2024

    NIH-funded brain mapping study uncovers which cell types may be harmed first.

    Alzheimer’s disease may damage the brain in two distinct phases, based on new research funded by the National Institutes of Health (NIH) using sophisticated brain mapping tools. According to researchers who discovered this new view, the first, early phase happens slowly and silently — before people experience memory problems — harming just a few vulnerable cell types. In contrast, the second, late phase causes damage that is more widely destructive and coincides with the appearance of symptoms and the rapid accumulation of plaques, tangles, and other Alzheimer’s hallmarks.

    “One of the challenges to diagnosing and treating Alzheimer’s is that much of the damage to the brain happens well before symptoms occur. The ability to detect these early changes means that, for the first time, we can see what is happening to a person’s brain during the earliest periods of the disease,” said Richard J. Hodes, M.D., director, NIH National Institute on Aging. “The results fundamentally alter scientists’ understanding of how Alzheimer’s harms the brain and will guide the development of new treatments for this devastating disorder.”

    Scientists analyzed the brains of 84 people, and the results, published in Nature Neuroscience, suggest that damage to one type of cell, called an inhibitory neuron, during the early phase may trigger the neural circuit problems that underlie the disease. Additionally, the study confirmed previous findings about how Alzheimer’s damages the brain and identified many new changes that may happen during the disease.

    Specifically, the scientists used advanced genetic analysis tools to study the cells of the middle temporal gyrus, a part of the brain that controls language, memory and vision. The gyrus has been shown to be vulnerable to many of the changes traditionally seen during Alzheimer’s. It is also a part of the brain that researchers have thoroughly mapped for control donors. By comparing control donor data with that from people who had Alzheimer’s, the scientists created a genetic and cellular timeline of what happens throughout the disease.

    Traditionally, studies have suggested that the damage caused by Alzheimer’s happens in several stages characterized by increasing levels of cell death, inflammation and the accumulation of proteins in the form of plaques and tangles. In contrast, this study suggests that the disease changes the brain in two “epochs” — or phases — with many of the traditionally studied changes happening rapidly during the second phase. This coincides with the appearance of memory problems and other symptoms.

    The results also suggest that the earliest changes happen gradually and “quietly” in the first phase before any symptoms appear. These changes include slow accumulation of plaques, activation of the brain’s immune system, damage to the cellular insulation that helps neurons send signals and the death of cells called somatostatin (SST) inhibitory neurons.

    The last finding was surprising to the researchers. Traditionally, scientists have thought that Alzheimer’s primarily damages excitatory neurons, which send activating neural signals to other cells. Inhibitory neurons send calming signals to other cells. The paper’s authors hypothesized how loss of SST inhibitory neurons might trigger the changes to the brain’s neural circuitry that underlie the disease.

    Recently, a separate NIH-funded brain mapping study by researchers at MIT found that a gene called REELIN may be associated with the vulnerability of some neurons to Alzheimer’s. It also showed that star-shaped brain cells called astrocytes may provide resilience to or resist the harm caused by the disease.

    Researchers analyzed brains that are part of the Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD), which is designed to create a highly detailed map of the brain damage that occurs during the disease. The project was led by Mariano I. Gabitto, Ph.D., and Kyle J. Travaglini, Ph.D., from the Allen Institute, Seattle. The scientists used tools — developed as part of the NIH’s Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative – Cell Census Network (BICCN) — to study more than 3.4 million brain cells from donors who died at various stages of Alzheimer’s disease. Tissue samples were obtained from the Adult Changes in Thought study and the University of Washington Alzheimer’s Disease Research Center.

    “This research demonstrates how powerful new technologies provided by the NIH’s BRAIN Initiative are changing the way we understand diseases like Alzheimer’s. With these tools, scientists were able to detect the earliest cellular changes to the brain to create a more complete picture of what happens over the entire course of the disease,” said John Ngai, Ph.D., director of The BRAIN Initiative®. “The new knowledge provided by this study may help scientists and drug developers around the world develop diagnostics and treatments targeted to specific stages of Alzheimer’s and other dementias.”

    This study was funded by NIH grants: U19AG060909, P30AG066509, U19AG066567, U01AG006781. Additional funding was provided by the Nancy and Buster Alvord Endowment. The Rush University Alzheimer’s Disease Center, Chicago, Il, shared donor metadata from the Religious Orders Memory/Memory and Aging Project.

    Researchers can obtain data from the SEA-AD study by going to the study’s website: https://portal.brain-map.org/explore/seattle-alzheimers-disease

    About the National Institute on Aging (NIA): NIA leads the U.S. federal government effort to conduct and support research on aging and the health and well-being of older people. Learn more about age-related cognitive change and neurodegenerative diseases via NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center website. Visit the main NIA website for information about a range of aging topics, in English and Spanish, and stay connected.

    The BRAIN Initiative, a multidisciplinary collaboration across 10 NIH Institutes and Centers, is uniquely positioned for cross-cutting discoveries in neuroscience to revolutionize our understanding of the human brain. By accelerating the development and application of innovative neurotechnologies, The BRAIN Initiative® is enabling researchers to understand the brain at unprecedented levels of detail in both health and disease, improving how we treat, prevent, and cure brain disorders. The BRAIN Initiative involves a multidisciplinary network of federal and non-federal partners whose missions and current research portfolios complement the goals of The BRAIN Initiative.

    About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

    NIH…Turning Discovery Into Health®

    Reference

    Gabitto, M. I.; Travaglini, K. J.; et al. Integrated multimodal cell atlas of Alzheimer’s disease. Nature Neuroscience. 2024 October 15 doi: 10.1038/s41593-024-01774-5

    ###

    MIL OSI USA News –

  • MIL-OSI USA: UConn Deepening Ties to Capital City With ‘UConn IN Hartford’ Initiative

    Source: US State of Connecticut

    Say the words, “UConn Hartford,” and what comes to mind? The stately former Hartford Times building that has served as the flagship university’s downtown campus since its much-hailed renovation and opening in 2017?

    While the main campus is the principal nexus of UConn’s presence in Connecticut’s capital city, it’s but one of a growing number of locations, programs, and initiatives underway that deepen the University’s ties with Hartford.

    In fact, UConn’s presence in Hartford continues to grow, including plans to offer 200 beds of student housing in the bustling downtown Pratt Street district, the recent opening of a nearby research center, the growth of local internships and a planned co-op program, and other initiatives.

    UConn is working with local and state leaders, the city and regional business community, alumni, and others on the “UConn IN Hartford” initiative, which seeks to provide students a community-centered experience in the capital city while they pursue their academics at UConn.

    Gov. Ned Lamont hears about UConn’s future in Hartford (Ashley Stimpson/UConn Foundation)

    Scores of those supporters gathered recently to learn more about the university’s plans and to tour 64 Pratt St., which will be transformed from its former use as a law office into apartment-style units for about 200 UConn Hartford students.

    Lexington Partners will work with Shelbourne Properties and LAZ Investments to jointly develop the apartments, and UConn will lease the space and run it as student housing starting in fall 2026 with on-site resident advisers and a hall director.

    It’s part of a broader vision shared by UConn, state and local leaders, and others to position Hartford as a “college town,” in which students are a major part of Hartford’s culture, economy, and future.

    “These dorms will be a huge boost to our capital city, bringing 200 more UConn students downtown who will reflect the diversity and incredible strength of our state, and who are going to make a name for themselves and change the world in so many different ways,” Hartford Mayor Arunan Arulampalam said at the recent reception.

    Hartford’s diversity is evident at the UConn campus, where the majority of students are either the first generation in their family to attend college, are students of color, or both.

    About 86% received some form of financial aid last year, and about 58% received federal Pell Grants, which are awarded to the neediest students.

    In a 2023 survey, about 70% of UConn Hartford undergraduates said that they would be interested in student housing nearby, but since most said they lived with their parents, the rent would need to be affordable to make it a viable option.

    To expand access to the Pratt Street housing opportunity, the UConn Foundation has launched the new Hartford Residential Scholars Enhancement Fund, which will harness community contributions to provide stipends for qualifying students who want to live in the apartments, but couldn’t otherwise afford it.

    The housing option and the initiative to help qualifying students with the costs are closely aligned with goals in the UConn Strategic Plan, which prioritizes holistic student success, access, affordability, and the strength of UConn’s regional campuses as integral to their host communities.

    Hartford Mayor Arunan Arulampalam says UConn’s plans will be a major boost for the city (Ashley Stimpson/UConn Foundation)

    For UConn Hartford students, the student housing will provide the dual benefit of living in the vibrant downtown setting while having the kinds of supports and community-centered experiences that dorm life offers.

    “Our job as a public university is to create access and opportunities for our students to learn and grow, and in turn they give back to the communities they come from. Right here, UConn Hartford provides a beacon of hope, opportunity, and transformation for our students,” said Mark Overmyer-Velázquez, UConn Hartford’s campus dean and chief administrative officer.

    UConn Hartford is a federally designated Asian American and Native American Pacific Islander Serving Institution and, with about 20% of its population identifying as Hispanic, it is on the threshold of reaching Hispanic Serving Institution status as an emerging HSI. It also has a rich history of engagement with the city in service, academics, and research.

    UConn Hartford students can take classes in more than 36 academic departments and can pursue 10 undergraduate programs and advanced degrees fully in Hartford through the School of Business, Neag School of Education, School of Public Policy, and School of Social Work. They may also elect to transfer to Storrs with the credits they have earned.

    “They have the ability to do all of that at the scale of a small liberal arts college, with all of the rich benefits that UConn offers as a Research 1 university,” Overmyer-Velázquez said.

    UConn’s presence in Hartford also includes the School of Law in the West End; the main campus at 10 Prospect St. and the nearby School of Social Work at 38 Prospect St.; UConn Health’s Health Disparities Institute at 241 Main St.; and the Graduate Business Learning Center, Connecticut Center for Entrepreneurship & Innovation’s BUILD Hartford course, both at Constitution Plaza.

    The newest UConn presence in Hartford is a big one: The University recently opened its new Community Intersections & Innovation Space for research and academic uses at 229 Trumbull St, also known as Hartford 21 (H21), very close to the student housing location.

    UConn is leasing space in that office building to house lecture halls, academic centers, classrooms, and faculty offices, providing opportunities to partner on support for community engagement, and on research projects and research grants.

    UConn President Radenka Maric talks with stakeholders about UConn’s future in Hartford (Ashley Stimpson/UConn Foundation)

    UConn moved its campus from West Hartford to its current location in 2017, and has worked since then to position it as a centerpiece of a thriving capital city by bringing people downtown to learn, live, and support the regional economy.

    The University has also significantly bolstered the wrap-around student services available UConn Hartford and other regional campuses. They include increasing medical and mental health care, adding Husky Harvest food pantries, helping students establish and expand clubs, boosting on-site career services, and other academic and social programs to help build a sense of community and support student success.

    Connecticut State House of Representatives Speaker Matt Ritter, D-Hartford (’07 LAW), noted at the recent reception that after the pandemic, many companies vacated their city office spaces as more employees worked remotely. Student housing like UConn’s planned units are a critical evolution in the vitality of those communities, he said.

    “This is such a big deal because of what it’s going to lead to,” Ritter said. “This is going to be what UConn is about: UConn changes the lives of young people and communities that it impacts.”

    MIL OSI USA News –

  • MIL-OSI United Kingdom: Restart a Heart Day 202414 October 2024 ​​​Staff from the States of Jersey Ambulance Service and members of the Health and Community Services Resuscitation Service will be teaching CPR and defibrillation techniques to members of the public for… Read more

    Source: Channel Islands – Jersey

    14 October 2024

    ​​​
    Staff from the States of Jersey Ambulance Service and members of the Health and Community Services Resuscitation Service will be teaching CPR and defibrillation techniques to members of the public for Restart a Heart Day, this coming Wednesday (16 October).

    ​Restart a Heart Day is an annual initiative, led by the Resuscitation Council (UK) to help people to learn CPR, and raise awareness and confidence in dealing with out of hospital cardiac arrest.

    UK statistics show that whereas only one in 25 victims of a cardiac arrest is likely to survive without receiving CPR, their chances increase to one in four where CPR takes place. 

    A stall will be set up next to the fountain on Broad Street between 09:00-14:00, to teach as many people as possible CPR and defibrillation skills.

    The event offers the chance for members of the public to try their hand at CPR, get to grips with a ‘defib’ and become more comfortable with what is involved, should they encounter someone who’s had a cardiac arrest. It takes just three minutes before damage to the brain can commence, and CPR can keep the blood flowing.

    Katie Campbell, Clinical Tutor for the States of Jersey Ambulance Service said: “Early CPR and defibrillation can double the chances of survival for someone who has suffered a cardiac arrest, so it is important as many people as possible know what to do in an emergency.

    “Restart a Heart Day is a brilliant initiative that spreads awareness and builds confidence to do the right thing in an emergency.”

    ​

    MIL OSI United Kingdom –

  • MIL-OSI Asia-Pac: Update on cluster of Rhinovirus/Enterovirus cases in Kwai Chung Hospital

    Source: Hong Kong Government special administrative region

    Update on cluster of Rhinovirus/Enterovirus cases in Kwai Chung Hospital
    Update on cluster of Rhinovirus/Enterovirus cases in Kwai Chung Hospital
    ************************************************************************

    The following is issued on behalf of the Hospital Authority:     Regarding an earlier announcement on a cluster of patients infected with Rhinovirus/Enterovirus in a ward of the learning disabilities, the spokesperson for Kwai Chung Hospital gave the following update today (October 14):     Two more female patients (aged 30 and 40) of the same ward have been presenting with respiratory symptoms since October 11. The patients are being treated in isolation and are in stable condition.     Enhanced infection control measures have already been adopted in the ward concerned according to prevailing guidelines. Droplet and contact precautions, hand hygiene, cleaning and disinfection of the environment and equipment have also been strengthened.      The hospital will continue to closely monitor the situation in the ward concerned. The case has been reported to the Hospital Authority Head Office and the Centre for Health Protection for follow-up.

     
    Ends/Monday, October 14, 2024Issued at HKT 18:17

    NNNN

    MIL OSI Asia Pacific News –

  • MIL-OSI NGOs: Remembering our colleagues killed in Gaza

    Source: Médecins Sans Frontières –

    We mourn the tragic loss of our colleagues who have been killed since the start of the war in Gaza in October 2023. We are outraged that many of these people were killed while providing care for patients or sheltering with their families. We remain deeply concerned for the safety of all our staff members and patients living under fire and siege.

    Nowhere in Gaza is safe. Israeli forces have repeatedly attacked health workers and medical facilities, making it nearly impossible for us to continue to provide lifesaving humanitarian assistance. MSF is calling for an end to attacks on health workers and health facilities. We are also demanding an immediate ceasefire in Gaza.

    Mohammed Al Ahel

    MSF lab technician killed on 6 November 2023.

    Mohammed Al Ahel was at his home in Al Shati refugee camp on 6 November  when the area was bombed and his building collapsed, reportedly killing dozens of people, including Mohammed and several members of his family. He was a laboratory technician and had been working with MSF for two years.

    Alaa Al Shawa

    MSF volunteer nurse supporting MSF teams at Al-Shifa hospital; killed 18 November 2023.

    Alaa was killed during an attack on an MSF convoy on 18 November while it was en route to southern Gaza to reach a safer place. “We arrived at the clinic and started to try to give Alaa life support, trying to stop the bleeding from his head,” said an anonymous MSF staff member present during the convoy attack. “We couldn’t do anything. He died while we were trying to save his life.”

    MSF had informed both parties to the conflict of the evacuation. The convoy followed the itinerary indicated by the Israeli army and reached Salah Al-Deen Street along with other civilians trying to leave the area. The convoy reached the last checkpoint near Wadi Gaza, which was overcrowded at that time due to extensive screenings of Palestinians by Israeli forces. Despite prior authorization from Israeli authorities, the MSF convoy wasn’t allowed to cross the checkpoint and was left waiting for hours. Shots were later heard by our staff, who out of fear decided to head back to the MSF premises, around four and a half miles north of the checkpoint.  

    On their way back, between 3:30 p.m. and 4:00 p.m. local time, the convoy was attacked on Al-Wahida Street near its junction with Said Al-A’as Street, close to MSF’s office. Two of the MSF cars were deliberately hit, killing Alaa and injuring a family member of another staff member, who later also died from his wound.

    “We stood up, just shocked by his death and all that had happened to us,” said another MSF staff member present that day. “I was speechless and just not able to think. My kids were crying and people were discussing how to bury our colleague.”

    Dr Ahmad Al Sahar.
    MSF

    Dr Ahmad Al Sahar

    MSF doctor killed on 21 November 2023.

    Dr Ahmad Al Sahar was killed in the 21 November strike on Al-Awda hospital that also killed MSF’s Dr Abu Nujaila and another doctor, Dr Ziad Al-Tatari. Dr Al Sahar and Dr Abu Nujaila were working when the hospital’s third and fourth floors were hit. MSF has regularly shared information about Al-Awda, including making it clear to warring parties that it is a functioning hospital with medical staff.

    Dr Mahmoud Abu Nujaila.
    MSF

    Dr Mahmoud Abu Nujaila

    MSF doctor killed on 21 November 2023.
     

    Dr Mahmoud Abu Nujaila was killed in a strike on Al-Awda Hospital in northern Gaza on November 21, along with MSF’s Dr Ahmad Al Sahar and another doctor, Dr Ziad Al-Tarari. Before his death, Dr. Abu Nujaila wrote a message on a whiteboard in the hospital normally used for planning surgeries: “Whoever stays until the end will tell the story. We did what we could. Remember us.”

    Reem Abu Lebdeh.
    Tetiana Gaviuk/MSF

    Reem Abu Lebdeh

    MSF physiotherapist and MSF UK board member killed in December 2023.

    Though the exact circumstances and date of Reem Abu Lebdeh’s death remain unclear, we believe she was killed along with members of her family at their home in Khan Younis in southern Gaza. Some members of her family remain unaccounted for.

    When the Israeli military campaign moved more extensively into Khan Younis over two months ago, we knew Reem was sheltering with her parents and siblings. Regrettably, contact with Reem was lost shortly thereafter and all attempts to regain it failed due to telecommunications networks being cut off.

    However, news of Reem’s death and that of her family members gradually emerged in the following weeks. To this day, the zone around their house, which was heavily bombarded by Israeli forces, remains too dangerous to approach.

    Reem worked as a physiotherapist for MSF in Gaza from 2018 until 2022, and last year was appointed as an associate trustee of the MSF UK Board.

    Fadi Al-Wadiya.
    MSF

    Fadi Al Wadiya

    MSF physiotherapist, killed 25 June 2024.

    Fadi Al-Wadiya was killed on June 25 along with five other people, including three children, near an MSF clinic in Gaza City. He was cycling to work at the time, on his way to provide medical care to others who had been injured. Fadi was a 33-year-old physiotherapist and father of three who joined MSF in 2018.

    On 26 June, Israeli authorities shared several posts on social media accusing Fadi of involvement in military activities in Gaza. MSF is deeply concerned by these allegations and is taking them very seriously.

    MSF has reached out to Israeli authorities asking for clarifications about the circumstances of Fadi’s killing. Only an independent investigation can establish the facts.

    Our colleague Nasser Hamdi Abdelatif Al Shalfouh.

    Nasser Hamdi Abdelatif Al Shalfouh

    MSF driver, killed 10 October 2024

    Nasser Hamdi Abdelatif Al Shalfouh died on 10 October after sustaining shrapnel injuries to his legs and chest on 8 October in Jabalia, north Gaza. Since 7 October, Jabalia was under relentless attacks by Israeli forces, and people were trapped, unable to flee. After being injured, Nasser first received emergency care at Al Awda hospital, Jabalia in north Gaza, and was later transferred to Kamal Adwan hospital. He is survived by his wife and two children.

    MIL OSI NGO –

  • MIL-Evening Report: ‘Awful reality’: Albanese government injects $95 million to fight the latest deadly bird flu

    Source: The Conversation (Au and NZ) – By Michelle Wille, Senior research fellow, The University of Melbourne

    The Australian government has committed A$95 million to fight a virulent strain of bird flu wreaking havoc globally.

    With the arrival of millions of migratory birds this spring, there is an increased risk of a deadly strain arriving in Australia, known as highly pathogenic avian influenza (HPAI) H5N1.

    Australia is the only continent free of this rapidly spreading strain. Overseas, HPAI H5N1 has been detected in poultry, wild birds and a wide range of mammals, including humans. But our reprieve will likely not last forever.

    As Environment Minister Tanya Plibersek warned on Monday, “the awful reality of this disease is that – like the rest of the world – we will not be able to prevent its arrival”. HPAI H5N1 is like nothing we’ve seen in Australia. The extra funding, which is in addition to Australia’s current biosecurity budget, will help us prepare and respond.

    A trail of destruction

    Avian influenza is a virus that infects birds, but can infect other animals.

    In Australia we have various strains of avian influenza that don’t cause disease, referred to as low pathogenic avian influenza. While these viruses occur naturally Australian wild birds, it is the disease-causing strains, such as HPAI H5N1 and HPAI H7 we are worried about. These HPAI strains have enormous consequences for wild birds, domestic animals, and animal producers and workers.

    HPAI H5N1 first emerged in Asia in 1996, and has been circulating in Asian poultry for decades. Following genetic changes in the virus, it repeatedly jumped into wild birds in 2014, 2016 and again in 2020, after which it caused an animal pandemic, or panzootic.

    Starting in 2021, the virus rapidly spread. First, from Europe to North America in 2021. Then into South America in 2022. There, in South America, the virus caused the death of more than 500,000 wild birds and 30,000 marine mammals.

    While we had seen large outbreaks in wild birds globally, the huge outbreaks in seals and sea lions in South America was unprecedented. With this came substantial concern that the virus was spreading from mammal to mammal, rather than just bird to bird or bird to mammal, as was happening elsewhere.

    About a year after arriving in South America, the virus was detected in the sub-Antarctic, and a few months later, on the Antarctic Peninsula.

    Australia and New Zealand are still free of the virus, for now.

    The rising death toll

    Beyond wildlife, HPAI H5N1 is having a huge impact on poultry.

    In 2022 alone, it caused 130 million poultry across 67 countries to die of the illness or be euthanased because they were infected.

    In contrast, earlier this year Australia’s biggest avian influenza outbreak to date – caused by a different strain, HPAI H7 – caused the death or destruction of 1.5 million chickens. That’s a drop in the bucket compared to what is occurring globally.

    Concerningly, in the United States, the virus has jumped into dairy cattle and so far has affected more than 200 dairy herds in 14 states. It has also jumping into humans: in the past ten days alone, six human cases have occurred – all in dairy workers in California.

    Given HPAI H5N1 has spread around the globe, the risk of the virus entering Australia has increased.

    In a recent risk assessment, my colleague and I identified two main pathways for H5N1 into Australia.

    The most likely route is that H5N1 is brought in from Asia by long-distance migratory birds. Birds such as shorebirds and seabirds arrive in the millions each spring from Asia (and in some cases as far away as Alaska).

    A second route is with ducks. If the virus spreads across the Wallace Line (a biogeographical boundary that runs through Indonesia), it will come into contact with endemic Australian duck species.

    Unlike shorebirds and seabirds, ducks are not long-distance migrants, and don’t migrate between Asia and Australia. That endemic Australian ducks are not exposed to this virus because they don’t migrate to Asia may be one of the reasons why H5N1 has not yet arrived in Australia.

    So, what’s the plan?

    The Australian government’s new $95 million funding commitment is a crucial response to the heightened level of risk, and the dire consequences if H5N1 entered the country.

    The funding is divided between environment, agriculture and human health – the three pillars of the “One Health” approach.

    Broadly, the money will be spent on:

    • enhancing surveillance to ensure timely detection and response if the disease enters and spreads in animals within Australia

    • strengthening preparedness and response capability to reduce harm to the production sector and native wildlife

    • supporting a nationally coordinated approach to response and communications

    • taking proactive measures to protect threatened iconic species from extinction

    • investing in more pre-pandemic vaccines to protect human health.

    Importantly, the funding covers preparedness, surveillance and response.

    Preparedness includes proactive measures to protect threatened birds – for example, vaccination or reducing other threats to these species) and improving biosecurity.

    Surveillance is essential to catch the virus as soon as it arrives and track its spread. Australia already has a wild bird surveillance program which, among other things, investigates sick and dead wildlife as well as sampling “healthy” wild birds. The additional commitment will bolster these activities.

    Response will include things like better and faster tests. It will also include funding for practical on-ground actions to limit the spread and impacts of HPAI H5N1 for susceptible wildlife. This might include a vaccination program for vulnerable threatened species, as an example.

    Work has already begun

    This funding is a long-term investment, and mostly allocated to future activities. In the short term, my colleagues and I have already begun our spring surveillance program.

    We aim to test about 1,000 long-distance migratory birds arriving in Australia for avian influenza. Based on our risk assessments, we are focusing on long-distance migratory seabirds such as the short-tailed shearwater, and various shorebirds including red-necked stints, arriving from breeding areas in Siberia.

    This surveillance program is supported by, and contributes to, the national surveillance program managed by Wildlife Health Australia

    In addition to our active surveillance, we need your help! If you see sick or dead wild birds or marine mammals, call the Emergency Animal Disease Watch Hotline on 1800 675 888.

    In addition, the Wildlife Health Australia website offers current advice for:

    For more information, visit birdflu.gov.au or Wildlife Health Australia’s avian influenza page

    Michelle Wille receives funding from Department of Agriculture, Fisheries and Forestry and Wildlife Health Australia.

    – ref. ‘Awful reality’: Albanese government injects $95 million to fight the latest deadly bird flu – https://theconversation.com/awful-reality-albanese-government-injects-95-million-to-fight-the-latest-deadly-bird-flu-241243

    MIL OSI Analysis – EveningReport.nz –

  • MIL-OSI: Global PROTAC Therapy Market Clinical Trials Drug Approval Insight

    Source: GlobeNewswire (MIL-OSI)

    Delhi, Oct. 14, 2024 (GLOBE NEWSWIRE) — Global PROTAC Targeted Protein Degraders Market Opportunity & Clinical Trials Insight 2027 Report Finding & Inclusions:

    • First PROTAC Drug Approval Expected By  2027
    • Global & Regional PROTAC Drug Market Trends Insight
    • First 12 Months & First 5 Years Market Size Estimates Since Approval
    • Global PROTAC Drugs Clinical Trials Insight By Company, Country, Indication & Phase: > 90 Drugs
    • FDA Fast Track & Orphan Drug Status Insight By Company & Indication
    • Comprehensive Insight On PROTAC Technology Platforms:  10 Platforms
    • Global PROTAC Drug Market Trends By Indications
    • Competitive Landscape
    Features Details
    Key Segments By Indication, By Region, Technology Platforms
    Therapeutic Areas Cancer, Infectious Diseases, Autoimmune & Inflammatory Diseases and others
    Countries Covered US, China, South Korea
    Report Coverage Mechanism of Action, Potential in Cancer, Comprehensive Clinical Drugs Insight, Current Trends and Future Opportunities
    Companies Covered Arvinas, EnhancedBio, Uppthera, TYK Medicine, Axter Therapeutics among others

    Download Report: https://www.kuickresearch.com/report-protac-targeted-protein-degraders-protac–therapy-protac-drug-approved

    Significant advancements have been made in the field of drug discovery in recent years with the aim of overcoming the drawbacks of conventional small-molecule therapies. Among these, the development of Proteolysis Targeting Chimeras, or PROTACs, is one of the most exciting developments. These dual-purpose compounds have become a cutting-edge method for selectively breaking down proteins, providing a special way to treat a range of diseases, such as cancer and neurological conditions.

    PROTACs are synthetic compounds designed  to specifically break down particular proteins by utilizing the ubiquitin-proteasome system (UPS) found in cells. Theoretically, in drug development, the ability to eradicate disease-associated proteins instead of simply blocking them presents a potent alternative. In this regard, PROTACs work by attracting an E3 ubiquitin ligase to the target protein, designating it for degradation, in contrast to conventional therapies that block protein activity. As a result of this process, the protein’s cellular levels are decreased, hence downregulating its activity.

    The mechanism of PROTACs is piloted by three key elements: an E3 ligase ligand, a target protein ligand, and a linker that joins the two. When a PROTAC molecule enters a cell, it recruits an E3 ligase and uses its ligand to attach to the target protein. The target protein is then signaled for proteasome breakdown by this ligase’s transfer of ubiquitin molecules. PROTACs are highly adaptable in drug development because of their modular structure, which makes it simple to create and optimize these compounds to target different proteins.

    The ability of PROTACs to selectively degrade particular proteins is one of their greatest advantages. A more favorable safety profile results from this tailored approach’s reduction of off-target effects, which are frequently linked to conventional small-molecule inhibitors. Resistance to conventional treatments is a hallmark of many diseases, including cancer. PROTACs may be able to get over these challenges and regain therapeutic efficacy by addressing the underlying proteins that cause resistance. Furthermore, PROTACs can also target proteins that are challenging to inhibit efficiently using conventional small molecules by taking advantage of the UPS. Many proteins implicated in disease pathways lack appropriate binding sites for small compounds, giving PROTACs an edge since they do not require particular binding sites on the target protein.

    Since the protein is eliminated from the cell when a PROTAC breaks down a target protein, the effects may endure for a long time and may result in long-lasting therapeutic benefits. One of the main areas of PROTAC development has been cancer treatment. PROTACs have been used to target particular oncoproteins, such as those implicated in signaling pathways that support tumor growth. In preclinical models, for example, PROTACs that target mutant variants of oncogenic proteins, such as KRAS, have demonstrated potential. PROTACs have the potential to produce longer-lasting remission and more substantial therapeutic effects by breaking down these proteins as opposed to just blocking them.

    Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, present unique challenges due to the accumulation of misfolded proteins that disrupt cellular function. PROTACs have demonstrated the ability to target these aggregated proteins for destruction, providing a unique therapeutic approach to slow the progression of the disease. For instance, studies are being conducted to create PROTACs that have the ability to specifically break down tau and α-synuclein protein aggregates, which are linked to Alzheimer’s and Parkinson’s diseases, respectively.

    Although PROTACs have shown promise in early clinical trials, more research is needed to assess their safety, effectiveness, and optimal dosing schedules. To advance this exciting area of study, collaboration among researchers, academics, and physicians is essential. For disorders that are difficult to treat with traditional methods, PROTACs offer a groundbreaking approach to therapy development. They use the body’s natural protein breakdown processes to specifically target and remove harmful proteins, which could lead to improved treatment options in oncology and other fields. With continued investigation, PROTACs have the potential to transform modern medicine and introduce a new era of targeted therapies.

    The MIL Network –

  • MIL-OSI United Kingdom: Eligible Leeds residents urged to protect themselves against viruses with free winter jabs

    Source: City of Leeds

    Leeds’s public health boss has issued a plea for all those eligible to take up the offer of a free flu vaccine this winter after worrying uptake levels last year.

    Leeds City Council’s director of public health has urged people to take the chance to protect themselves against both the flu and Covid 19, with both viruses spreading more easily in winter as people spend increasing amounts of time indoors together.  

    The winter vaccine programme focuses on those at greatest risk of getting seriously ill – including people with long-term health conditions, people aged over 65 and pregnant women – yet last year Leeds saw lower uptakes of the free annual jabs among some of these cohorts.

    While uptake in older people remained high (79.5 per cent of over 65s), less than four in 10 (39 per cent) of people deemed ‘at risk’ received the flu vaccine, with similarly low levels seen among pregnant women (38 per cent) and two- to three-year-olds (37 per cent).

    It comes as national figures from the UK Health Security Agency (UKHSA) show that over the past two winters at least 18,000 deaths across the UK were associated with flu, despite last winter being a relatively mild flu season.

    For the first time this year, pregnant women and older people aged 75 to 79 are also eligible for the RSV (respiratory syncytial virus) vaccination, with the maternal vaccine providing strong protection for newborns in their first few months, when they are most at risk of severe illness from RSV. Pregnant women should speak to their GP or maternity team for more information.

    Leeds City Council’s director of public health Victoria Eaton said: “After clean water, immunisation is the most effective public health intervention in the world for saving lives and promoting good health.

    “Over the winter period, even if you have had a vaccine or been ill with flu, Covid 19 or RSV before, it’s vital that you top up your protection as immunity fades over time and these viruses can change each year.

    “It is therefore extremely important that anyone eligible to receive their winter vaccinations takes up the potentially life-saving opportunity. The national mortality figures are a stark reminder of how deadly these viruses can be to those at risk.

    “Receiving the vaccinations means that if you do catch any of these viruses, you are likely to have milder symptoms and recover faster, cutting your risk of being hospitalised.

    “I’m urging all those eligible to join the millions of others across the UK in taking up their free vaccine offer to ensure they stay winter strong.”

    Councillor Fiona Venner, Leeds City Council’s executive member for equality, health and wellbeing, said: “We want to protect our city’s most vulnerable from these respiratory viruses which spread more easily in winter and usually reach their peak over the festive and new year period.

    “Nobody wants to miss out on festive celebrations with their families and friends and these vaccines provide the best possible protection.

    “Our city’s GPs and community pharmacies stand ready to provide these free jabs to all those eligible – please book your appointment today and arm yourself against the risk of severe illness.”

    Over 65s, those under 65 in clinical risk groups and pregnant women should contact their GP surgery or community pharmacy (for those aged 18 or over) to book their vaccinations.

    Parents of children who are aged two or three (on or before August 31, 2024) should contact their GP surgery to book their child’s flu vaccination.

    School-aged children (from reception to year 11) will mainly be offered their flu vaccines at school and for most this is a nasal spray, not an injection. A flu vaccine injection is available that does not contain gelatine. Parents who do not want their child to have the nasal spray vaccine should speak to the person vaccinating the child or ask for the injection on the school consent form.  

    For full details, to check eligibility and to book online, visit at http://www.nhs.uk/wintervaccinations.

    ENDS

    For media enquiries please contact:

    Leeds City Council communications and marketing,

    Email: communicationsteam@leeds.gov.uk

    Tel: 0113 378 6007

    MIL OSI United Kingdom –

  • MIL-OSI United Kingdom: Landmark collaboration with largest pharmaceutical company

    Source: United Kingdom – Executive Government & Departments

    Collaboration announced at International Investment Summit, meeting the PM’s ambitions to catalyse investment in the UK, proving the UK is open for business. 

    The UK’s world leading life sciences sector will receive a £279 million boost to tackle significant health challenges, with an intent expressed by Lilly, the world’s largest pharmaceutical company, to invest in the UK, as part of a collaborative partnership with UK Government, announced at the International Investment Summit today (Monday 14 October).

    Plans to form a new collaboration through a memorandum of understanding will see the pharmaceutical giant backing the UK’s brightest and best life sciences talent with the planned launch of the first ‘Lilly Gateway Labs’ innovation accelerator in Europe. This facility will support early-stage life sciences businesses to develop transformative medicines by providing lab space, mentorship, and potential financial backing to rocket future growth in the sector.   

    Health and Social Care Secretary Wes Streeting said: 

    For all the challenges facing the health of our nation, we have two huge advantages: some of the world’s leading scientific minds, and a National Health Service with enormous potential. If we can combine the two, patients in this country can reap the rewards of the revolution in medical science unfolding before our eyes.

    This announcement helps the UK take its place as a world leader in life sciences and brings life-changing treatments closer to being a reality for NHS patients. Partnerships like this are key to building a healthier society, healthier economy, and making the NHS fit for the future.  

    Lilly’s Gateway Lab plans build on the 300,000 jobs the life sciences sector already supports nationwide. The facility will be the first announced anywhere in Europe, cementing the UK as a world leader in healthcare.  

    Science and Technology Secretary Peter Kyle said:

    The UK’s life sciences sector is at the forefront of pioneering and life-saving research. 

    This ground-breaking collaboration is proof that this sector is held in high esteem internationally and is driving investment into the UK. 

    Investments like this drive forward work that will boost our health and ultimately save lives.

    But they also fire up our economy, creating the jobs, opportunity and growth we need to invest further in health and to push up living standards.

    David A. Ricks, Chair and CEO of Eli Lilly & Company said:

    We welcome this opportunity to partner with the UK Government on tackling and preventing disease, and accelerating innovation to advance care delivery models. Today’s announcement is an important milestone, and we are pleased to reinforce Lilly’s commitment to improving health for people living with obesity and its serious consequences.

    Obesity is the second biggest preventable cause of cancer and a major contributor to ill-health that prevents people from participating fully in work. This collaboration will bring together treatments and technologies developed by the life sciences sector and the health system seeking to demonstrate improved long-term health outcomes for those living with obesity. 

    The collaboration with Lilly aims to set the stage for Government to work with industry to trial innovative approaches to treating obesity as part of a rounded package of care. 

    With obesity costing the UK health service more than £11 billion each year, action to tackle the condition is urgently needed. Backing the UK life sciences sector to understand obesity further, alongside introducing measures to prevent obesity in the first place such as restrictions on junk food advertising, will help ease pressure on the NHS.

    NHS chief executive Amanda Pritchard said: 

    Obesity is one of the biggest public health issues we face, and we know weight loss drugs will be a game-changer, alongside earlier prevention strategies, in supporting many more people to lose weight and reduce their risk of killer conditions like diabetes, heart attack and stroke.

    Today’s momentous agreement shows the NHS is uniquely well-placed globally, not just to bring effective new treatments to those who would benefit most, but also to support science, research, jobs and economic growth across the country. We now have an important chance to gain a better understanding of the benefits of weight management interventions for patients, and how best to deliver them over the next few years.

    Today’s collaboration is a demonstration of the £108 billion life sciences sector’s value to the UK economy, in both improving public health and keeping the UK at the forefront of scientific progress.  

    Mayor of Greater Manchester, Andy Burnham, said:

    Greater Manchester is world-renowned as a hub for innovation in health and life sciences. The results of the trial announced today could have a far-reaching impact on how we treat obesity globally, and our city-region is ready to make a significant contribution through our outstanding health data assets, R&D expertise, and the strong partnerships between industry, universities and public sector organisations.

    The International Investment Summit will provide an opportunity to showcase our local strengths in health innovation to an audience of global business leaders and investors. This partnership could be the first of many and give Greater Manchester residents access to other innovative treatments.

    Scotland’s Cabinet Secretary for Health and Social Care, Neil Gray, said:

    I welcome this long term strategic partnership with the world’s largest pharmaceutical company.

    Scotland has a vibrant life science sector, world class universities and an NHS with a long track record of working with both.

    This initiative supports our use of innovation to transform health and social care by building new partnerships between government, our NHS, academic institutions, and industry.

    Mike Nesbitt, Health Minister for Northern Ireland, said:

    It is only by focusing more on prevention and population health, tackling health inequalities and harnessing the power of innovation through the UK’s world-leading life sciences sector that we will be able to deliver better outcomes for patients.

    Driving economic growth to improve the lives of hardworking British people is this Government’s number one mission. The life sciences sector – which drove £800 million in foreign direct investment into the UK in 2023 – sits at the heart of these plans.

    ENDS 

    Notes for editors 

    About the Obesity Healthcare Goals Programme: 

    • The Obesity Healthcare Goals Programme, formerly known as the Obesity Mission, was announced in November 2022, and is being delivered by the Office for Life Sciences (OLS) alongside the Dementia, Mental Health, Cancer and Addiction Healthcare Goals.

    Updates to this page

    Published 14 October 2024

    MIL OSI United Kingdom –

  • MIL-OSI USA: Nguyen a Biomedical Engineering Star

    Source: US State of Connecticut

    Through millions in coveted grants, the National Institutes of Health (NIH) and the Bill and Melinda Gates Foundation are recognizing how impactful Thanh Nguyen’s research is to the field of biomedical engineering.

    Nguyen, an associate professor of mechanical engineering and biomedical engineering, has already established himself as one of the top-funded researchers at UConn. The NIH is adding to that success by awarding Nguyen four R01 grants totaling more than $9.5 million, with $7.5 million going to UConn researchers.

    His research is the interface of biomedicine, material engineering, and the use of nano- and microtechnology.  Nguyen has made strides on multiple fronts, with multi-disciplinary projects dedicated to helping heal helping people with diverse afflictions.

    “We are always motivated by medical problems that have a high impact on human health,” says Nguyen.

    R01 grants are highly competitive, awarded to research and development projects that live up to the NIH’s mission to improve health, extend life, and reduce illness and disability.

    For Nguyen, his collaborators, and students, the grants present an opportunity to improve technology to help bones and cartilage to heal. He is also working to develop improved methods to deliver lifesaving vaccines and antibodies to worldwide populations.

    Assistant professor Thanh Nguyen supports numerous postdoctoral and Ph.D. students in his biomedical engineering laboratory.

    Two of the grants are brand new, providing $2.1 million and $1.5 million toward respective projects. On the former, Nguyen is the primary investigator on a project to stimulate and accelerate healing defects to the longest bones in the body, such as the femur and tibia.

    “Bones in most parts of the body can regenerate themselves, but when you get a long and large bone injury, the body needs help to regenerate,” Nguyen says.

    Significant long bone injuries are often treated with growth factors or stem cells to stimulate healing. However, the techniques often include serious side effects that can impair patients.

    Nguyen and his team are working to minimize the danger through the application of safe biomaterials as an electrically active scaffold over a bone defect. The scaffold would be biodegradable and able to produce electrical charges, stimulating bone repair.

    Concurrently, Nguyen is working with fellow researchers to provide needed antibodies to breastfeeding infants with HIV. Globally, more than 130,000 babies are infected with HIV annually, and certain antibodies have shown to be effective against the virus.

    The second new R01 grant will fund the development microneedle technology to deliver multi-potent antibodies which can last a long time in the baby body to sustain the immune protection against infectious HIV virus. Currently, multiple injections are required, and the antibodies must be stored at cold temperatures. The process is expensive and burdensome.

    Nguyen says microneedle patches would greatly simplify the process and reduce the cost of cold-chain storage. Along with the collaborators in Eastern Virginia Medical School (EVMS), Nguyen’s research would investigate the effectiveness of the anti-HIV patches in small animals and large animals like monkeys.

    Nguyen says the treatment is applied similar to a nicotine patch, painlessly delivering the antibodies into the recipient. Ultimately, the patches will be tested in pediatric patients who have a high risk of HIV infection as a result of breastfeeding from HIV-infected mothers.

    Besides these two grants, he received a $2.16 million grant to research how his invented biodegradable ultrasound technology can increase the effectiveness of chemotherapy in brain cancer patients.

    The fourth grant, for nearly $2 million, investigates how tissue-scaffolding made of his lab’s invented biodegradable electrically active polymer can regrow cartilage, as successfully performed on rabbits. The treatment could be a game changer for osteoarthritis patients whose cartilage in body parts such as the knee has deteriorated through injury or aging.

    Beyond the NIH, Nguyen has received significant support through the Bill and Melinda Gates Foundation in a $2.6 million project as the PI on development of a microneedle array patch capable of delivering multiple human vaccines at once.

    In late September, the Gates Foundation awarded Nguyen another $4 million for his work on the microneedle patch. Nguyen and his team are working to scale up production of the patch, which can deliver multiple vaccines at ones. This includes vaccines or antibodies to fight diphtheria, tetanus, pertussis, HIV, and polio.

    Once almost eradicated, polio continues to affect populations in developing countries, with the most cases reported in Afghanistan and neighboring Pakistan. Nguyen hopes the microneedle patch will make new progress in the effort to eliminate the threat of polio once and for all.

    Now with $6.6 million in Gates Foundation funding, Nguyen is pleased to be able to expand his team, including offer more opportunities to undergraduate and postgraduate students.

    Together, his prolific research funding has brought a total amount of $25 million funding to UConn since 2016 when he started as an assistant professor, a testament to the impact of his research.

    “I am very grateful to the NIH and the Gates Foundation for the opportunity to pursue vaccination and biomedical engineering research at UConn,” Nguyen says.

    Nguyen’s breakthroughs have led to numerous awards, more than 20 issued and pending patents, and an induction into the U.S. National Academy of Inventors. He is also a reputable mentor, adviser and collaborator, with his work currently supporting more than 21 people, including 11 post-doctoral and 10 Ph.D. students in his biomedical engineering lab.

    While he has been successful as a fundraiser, Nguyen says it has taken many years and widespread publication to achieve his level of support. He backs his proposals through innovative ideas, significant problems to address and extensive scientific data, utilizing the resources at his disposal.

    “We keep working and producing high quality research published in well-known scientific journals,” he says. “That has helped create a successful and impactful research program.”

    MIL OSI USA News –

  • MIL-OSI Global: Scientists around the world report millions of new discoveries every year − but this explosive research growth wasn’t what experts predicted

    Source: The Conversation – USA – By David P. Baker, Professor of Sociology, Education and Demography, Penn State

    The number of research studies published globally has risen exponentially in the past decades. AP Photo/Frank Augstein, file

    Millions of scientific papers are published globally every year. These papers in science, technology, engineering, mathematics and medicine present discoveries that range from the mundane to the profound.

    Since 1900, the number of published scientific articles has doubled about every 10 to 15 years; since 1980, about 8% to 9% annually. This acceleration reflects the immense and ever-growing scope of research across countless topics, from the farthest reaches of the cosmos to the intricacies of life on Earth and human nature.

    Derek de Solla Price wrote an influential book about the growth rate of science.
    The de Solla Price family/Wikimedia Commons

    Yet, this extraordinary expansion was once thought to be unsustainable. In his influential 1963 book, “Little Science, Big Science… And Beyond,” the founder of scientometrics – or data informetrics related to scientific publications – Derek de Solla Price famously predicted limits to scientific growth.

    He warned that the world would soon deplete its resources and talent pool for research. He imagined this would lead to a decline in new discoveries and potential crises in medicine, technology and the economy. At the time, scholars widely accepted his prediction of an impending slowdown in scientific progress.

    Faulty predictions

    In fact, science has spectacularly defied Price’s dire forecast. Instead of stagnation, the world now experiences “global mega-science” – a vast, ever-growing network of scientific discovery. This explosion of scientific production made Price’s prediction of collapse perhaps the most stunningly incorrect forecast in the study of science.

    Unfortunately, Price died in 1983, too early to realize his mistake.

    So, what explains the world’s sustained and dramatically increasing capacity for scientific research?

    We are sociologists who study higher education and science. Our new book, “Global Mega-Science: Universities, Research Collaborations, and Knowledge Production,” published on the 60th anniversary of Price’s fateful prediction, offers explanations for this rapid and sustained scientific growth. It traces the history of scientific discovery globally.

    Factors such as economic growth, warfare, space races and geopolitical competition have undoubtedly spurred research capacity. But these factors alone cannot account for the immense scale of today’s scientific enterprise.

    The education revolution: Science’s secret engine

    In many ways, the world’s scientific capacity has been built upon the educational aspirations of young adults pursuing higher education.

    Funding from higher education supports a large part of the modern scientific enterprise.
    AP Photo/Paul Sancya

    Over the past 125 years, increasing demand for and access to higher education has sparked a global education revolution. Now, more than two-fifths of the world’s young people ages 19-23, although with huge regional differences, are enrolled in higher education. This revolution is the engine driving scientific research capacity.

    Today, more than 38,000 universities and other higher-education institutions worldwide play a crucial role in scientific discovery. The educational mission, both publicly and privately funded, subsidizes the research mission, with a big part of students’ tuition money going toward supporting faculty.

    These faculty scientists balance their teaching with conducting extensive research. University-based scientists contribute 80% to 90% of the discoveries published each year in millions of papers.

    External research funding is still essential for specialized equipment, supplies and additional support for research time. But the day-to-day research capacity of universities, especially academics working in teams, forms the foundation of global scientific progress.

    Even the most generous national science and commercial research and development budgets cannot fully sustain the basic infrastructure and staffing needed for ongoing scientific discovery.

    Likewise, government labs and independent research institutes, such as the U.S. National Institutes of Health or Germany’s Max Planck Institutes, could not replace the production capacity that universities provide.

    Collaboration benefits science and society

    The past few decades have also seen a surge in global scientific collaborations. These arrangements leverage diverse talent from around the world to enhance the quality of research.

    International collaborations have led to millions of co-authored papers. International research partnerships were relatively rare before 1980, accounting for just over 7,000 papers, or about 2% of the global output that year. But by 2010 that number had surged to 440,000 papers, meaning 22% of the world’s scientific publications resulted from international collaborations.

    This growth, building on the “collaboration dividend,” continues today and has been shown to produce the highest-impact research.

    Universities tend to share academic goals with other universities and have wide networks and a culture of openness, which makes these collaborations relatively easy.

    Today, universities also play a key role in international supercollaborations involving teams of hundreds or even thousands of scientists. In these huge collaborations, researchers can tackle major questions they wouldn’t be able to in smaller groups with fewer resources.

    Supercollaborations have facilitated breakthroughs in understanding the intricate physics of the universe and the synthesis of evolution and genetics that scientists in a single country could never achieve alone.

    The IceCube collaboration, a prime example of a global megacollaboration, has made big strides in understanding neutrinos, which are ghostly particles from space that pass through Earth.
    Martin Wolf, IceCube/NSF

    The role of global hubs

    Hubs made up of universities from around the world have made scientific research thoroughly global. The first of these global hubs, consisting of dozens of North American research universities, began in the 1970s. They expanded to Europe in the 1980s and most recently to Southeast Asia.

    These regional hubs and alliances of universities link scientists from hundreds of universities to pursue collaborative research projects.

    Scientists at these universities have often transcended geopolitical boundaries, with Iranian researchers publishing papers with Americans, Germans collaborating with Russians and Ukrainians, and Chinese scientists working with their Japanese and Korean counterparts.

    The COVID-19 pandemic clearly demonstrated the immense scale of international collaboration in global megascience. Within just six months of the start of the pandemic, the world’s scientists had already published 23,000 scientific studies on the virus. These studies contributed to the rapid development of effective vaccines.

    With universities’ expanding global networks, the collaborations can spread through key research hubs to every part of the world.

    Is global megascience sustainable?

    But despite the impressive growth of scientific output, this brand of highly collaborative and transnational megascience does face challenges.

    On the one hand, birthrates in many countries that produce a lot of science are declining. On the other, many youth around the world, particularly those in low-income countries, have less access to higher education, although there is some recent progress in the Global South.

    Sustaining these global collaborations and this high rate of scientific output will mean expanding access to higher education. That’s because the funds from higher education subsidize research costs, and higher education trains the next generation of scientists.

    De Solla Price couldn’t have predicted how integral universities would be in driving global science. For better or worse, the future of scientific production is linked to the future of these institutions.

    David Baker receives funding from the U.S. National Science Foundation, U.S. National Institutes of Health, Fulbright, FNR
    Luxembourg, and the Qatar Nation Research Fund.

    Justin J.W. Powell has received funding for research on higher education and science from Germany’s BMBF, DFG, and VolkswagenStiftung; Luxembourg’s FNR; and Qatar’s QNRF.

    – ref. Scientists around the world report millions of new discoveries every year − but this explosive research growth wasn’t what experts predicted – https://theconversation.com/scientists-around-the-world-report-millions-of-new-discoveries-every-year-but-this-explosive-research-growth-wasnt-what-experts-predicted-237274

    MIL OSI – Global Reports –

  • MIL-OSI Global: Godzilla at 70: The monster’s warning to humanity is still urgent

    Source: The Conversation – USA – By Amanda Kennell, Assistant Professor of East Asian Languages and Cultures, University of Notre Dame

    The monster in the 2023 movie “Godzilla Minus One.” Toho Co. Ltd., CC BY-ND

    The 2024 Nobel Peace Prize has been awarded to Nihon Hidankyo, the Japan Confederation of A- and H-bomb Sufferers Organizations. Many of these witnesses have spent their lives warning of the dangers of nuclear war – but initially, much of the world didn’t want to hear it.

    “The fates of those who survived the infernos of Hiroshima and Nagasaki were long concealed and neglected,” the Nobel committee noted in its announcement. Local groups of nuclear survivors created Nihon Hidankyo in 1956 to fight back against this erasure.

    Atomic bomb survivor Masao Ito, 82, speaks at the park across from the Atomic Bomb Dome in Hiroshima in May 15, 2023.
    Richard A. Brooks/AFP via Getty Images

    Around the same time that Nihon Hidankyo was formed, Japan produced another warning: a towering monster who topples Tokyo with blasts of irradiated breath. The 1954 film “Godzilla” launched a franchise that has been warning viewers to take better care of the Earth for the past 70 years.

    We study popular Japanese media and business ethics and sustainability, but we found a common interest in Godzilla after the 2011 earthquake, tsunami and meltdown at Japan’s Fukushima Daiichi nuclear plant. In our view, these films convey a vital message about Earth’s creeping environmental catastrophe. Few survivors are left to warn humanity about the effects of nuclear weapons, but Godzilla remains eternal.

    Into the atomic age

    By 1954, Japan had survived almost a decade of nuclear exposure. In addition to the bombings of Hiroshima and Nagasaki, the Japanese people were affected by a series of U.S. nuclear tests in the Bikini Atoll.

    When the U.S. tested the world’s first hydrogen bomb in 1954, its devastation reached far outside the expected damage zone. Though it was far from the restricted zone, the Lucky Dragon No. 5 Japanese fishing boat and its crew were doused with irradiated ash. All fell ill, and one fisherman died within the year. Their tragedy was widely covered in the Japanese press as it unfolded.

    The Castle Bravo hydrogen bomb test on March 1, 1954, produced an explosion equivalent to 15 megatons of TNT, more than 2.5 times what scientists had expected. It released large quantities of radioactive debris into the atmosphere.

    This event is echoed in a scene at the beginning of “Godzilla” in which helpless Japanese boats are destroyed by an invisible force.

    “Godzilla” is full of deep social debates, complex characters and cutting-edge special effects for its time. Much of the film involves characters discussing their responsibilities – to each other, to society and to the environment.

    This seriousness, like the film itself, was practically buried outside of Japan by an alter ego, 1956’s “Godzilla, King of the Monsters!” American licensors cut the 1954 film apart, removed slow scenes, shot new footage featuring Canadian actor Raymond Burr, spliced it all together and dubbed their creation in English with an action-oriented script they wrote themselves.

    This version was what people outside of Japan knew as “Godzilla” until the Japanese film was released internationally for its 50th anniversary in 2004.

    From radiation to pollution

    While “King of the Monsters!” traveled the world, “Godzilla” spawned dozens of Japanese sequels and spinoffs. Godzilla slowly morphed from a murderous monster into a monstrous defender of humanity in the Japanese films, which was also reflected in the later U.S.-made films.

    In 1971, a new, younger creative team tried to define Godzilla for a new era with “Godzilla vs. Hedorah.” Director Yoshimitsu Banno joined the movie’s crew while he was promoting a recently completed documentary about natural disasters. That experience inspired him to redirect Godzilla from nuclear issues to pollution.

    World War II was fading from public memory. So were the massive Anpo protests of 1959 and 1960, which had mobilized up to one-third of the Japanese people to oppose renewal of the U.S.-Japan security treaty. Participants included housewives concerned by the news that fish caught by the Lucky Dragon No. 5 had been sold in Japanese grocery stores.

    At the same time, pollution was soaring. In 1969, Michiko Ishimure published “Paradise in the Sea of Sorrow: Our Minamata Disease,” a book that’s often viewed as a Japanese counterpart to “Silent Spring,” Rachel Carson’s environmental classic. Ishimure’s poetic descriptions of lives ruined by the Chisso Corp.’s dumping of methyl mercury into the Shiranui Sea awoke many in Japan to their government’s numerous failures to protect the public from industrial pollution.

    The Chisso Corp. released toxic methylmercury into Minamata Bay from 1932 to 1968, poisoning tens of thousands of people who ate local seafood.

    “Godzilla vs. Hedorah” is about Godzilla’s battles against Hedorah, a crash-landed alien that grows to monstrous size by feeding on toxic sludge and other forms of pollution. The film opens with a woman singing jazzily about environmental apocalypse as young people dance with abandon in an underground club.

    This combination of hopelessness and hedonism continues in an uneven film that includes everything from an extended shot of an oil slick-covered kitten to an animated sequence to Godzilla awkwardly levitating itself with its irradiated breath.

    After Godzilla defeats Hedorah at the end of the film, it pulls a handful of toxic sludge out of Hedorah’s torso, gazes at the sludge, then turns to stare at its human spectators – both those onscreen and the film’s audience. The message is clear: Don’t just lazily sing about imminent doom – shape up and do something.

    Official Japanese trailer for ‘Godzilla vs. Hedorah’

    “Godzilla vs. Hedorah” bombed at the box office but became a cult hit over time. Its positioning of Godzilla between Earth and those who would harm it resonates today in two separate Godzilla franchises.

    One line of movies comes from the original Japanese studio that produced “Godzilla.” The other line is produced by U.S. licensors making eco-blockbusters that merge the environmentalism of “Godzilla” with the spectacle of “King of the Monsters.”

    A meltdown of public trust

    The 2011 Fukushima disaster has now become part of the Japanese people’s collective memory. Cleanup and decommissioning of the damaged nuclear plant continues, amid controversies around ongoing releases of radioactive water used to cool the plant. Some residents are allowed to visit their homes but can’t move back there while thousands of workers remove topsoil, branches and other materials to decontaminate these areas.

    Before Fukushima, Japan derived one-third of its electricity from nuclear power. Public attitudes toward nuclear energy hardened after the disaster, especially as investigations showed that regulators had underestimated risks at the site. Although Japan needs to import about 90% of the energy it uses, today over 70% of the public opposes nuclear power.

    The first Japanese “Godzilla” film released after the Fukushima disaster, “Shin Godzilla” (2016), reboots the franchise in a contemporary Japan with a new type of Godzilla, in an eerie echo of the damages of and governmental response to Fukushima’s triple disaster. When the Japanese government is left leaderless and in disarray following initial counterattacks on Godzilla, a Japanese government official teams up with an American special envoy to freeze the newly named Godzilla in its tracks, before a fearful world unleashes its nuclear weapons once again.

    Their success suggests that while national governments have an important role to play in major disasters, successful recovery requires people who are empowered to act as individuals.

    The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

    – ref. Godzilla at 70: The monster’s warning to humanity is still urgent – https://theconversation.com/godzilla-at-70-the-monsters-warning-to-humanity-is-still-urgent-237934

    MIL OSI – Global Reports –

  • MIL-OSI Global: How Mpox anti-vaxx conspiracies target and stigmatise LGBTQ+ people

    Source: The Conversation – UK – By Helen McCarthy, Doctoral Researcher in Criminology and Sociology, York St John University

    According to some conspiracy theorists posting on alternative, uncensored social media networks, Mpox is another “scamdemic”, created by a powerful elite to cull populations and generate profit for “big pharma”. According to these social media users, anyone who takes the Mpox vaccine inevitably faces heart attack and death.

    Other Mpox conspiracies target hate at LGBTQ+ people.

    Through my PhD research into anti-vaccination misinformation, I’ve collected thousands of social media posts, videos, images and links from anti-vaccination Telegram channels, Substack newsletters and Gab groups. Gab Social is a social networking site known for hosting right-wing political content. These platforms are unique in their permissive approach to moderation. Users can post virtually anything they want without restraint.

    According to 2023 research, platforms like Gab have become the home of many “alt-right” content creators who have been de-platformed from mainstream social media channels like Facebook and Instagram. Mpox misinformation is thriving in these online locations.

    Sexuality and stigma

    In the early days of the COVID pandemic, a study identified that misinformation on social media platforms like Facebook, X (formerly known as Twitter) and YouTube frequently blamed specific social groups for infection surges. Now, it’s MPox’s turn.

    One Substack creator, for example, considers gay and bisexual men engaging in “high-risk sexual behaviour” a threat to the heterosexual population. He argues abstinence is the only solution – but only for men who have sex with men.

    As well as accusing gay and bisexual men of having a “perverted lifestyle that goes against nature and God’s laws”, some anti-vaxx content creators stigmatise people with Mpox as a hidden enemy, who could be “teaching in schools and indoctrinating children”.

    One common anti-vaxx conspiracy theory is “vaccine shedding”. This is the idea that vaccinated people can harm the unvaccinated through any kind of contact. One online conspiracy states the Mpox vaccine is particularly prone to shedding. Gay and bisexual men, then, are portrayed as dangerous whether they’re vaccinated or not.

    Mpox is routinely characterised by conspiracy theorists as a virus for immoral people. As a result, some anti-vaxx perspectives are shockingly callous – one commenter claims they wouldn’t care at all if “the gays and communists” died from the Mpox vaccine.

    Misinformation surrounding Mpox and the vaccine is peppered with such homophobic narratives of infection and contamination – and it’s familiar territory. People suffering from HIV and Aids in the 1980s and 1990s were relentlessly stigmatised as a dangerous other.

    While online conspiracy theories present those with Mpox as a menace, in reality, there have only been a small number of mild Mpox cases identified in the UK since 2022. Though the majority of confirmed cases of Mpox in the UK have been in gay and bisexual men – and Mpox can be transmitted through close sexual contact – people can also become infected if they’re exposed to coughing and sneezing, or share clothing, bedding and towels with an infected person.

    Moderation and misinformation

    In August 2024, a new strain of Mpox was identified in the Democratic Republic of the Congo and some neighbouring countries. An estimated 10 million vaccines are needed to meet demand in affected African nations. In September 2024, the UK government ordered 150,000 doses of an Mpox vaccine to be distributed among gay and bisexual men and healthcare and humanitarian workers who may be exposed.

    Just as many of us might check a reliable, verified medical source to find out more about Mpox, so alternative social media users look to the sources they trust. This commonly includes doctors blowing the whistle on alleged vaccine injury, conspiracy theory “news” sites and prominent right wing figures like Tucker Carlson. People selling alternative remedies and products promising miraculous detox are never far away to profit from vaccine misinformation.

    Users share these sources across Gab groups, comment threads and Telegram channels, layering their own beliefs on top. This generates even more views and shares, which is one of the reasons why social media is such a good incubator for conspiracy theories and misinformation.

    Another reason is the lack of content moderation on alternative social media sites. Substack describes itself as “a place for independent writing”. Users are not supposed to share any content which incites violence, contains sex or nudity, or illegal activity. Telegram takes a similar approach. Gab also draws the line at illegal content, but mainly encourages users to hide content they don’t want to see or ignore it.

    The arguments for or against unrestrained free speech on the internet are complex. But sites like Gab reveal what an unmoderated internet can look like – hate of every variety can find a home here if that’s what the users choose to post. Mpox is just another topic to generate even more shareable content.

    Helen McCarthy does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

    – ref. How Mpox anti-vaxx conspiracies target and stigmatise LGBTQ+ people – https://theconversation.com/how-mpox-anti-vaxx-conspiracies-target-and-stigmatise-lgbtq-people-239981

    MIL OSI – Global Reports –

  • MIL-OSI Global: Too many kids face bullying rooted in social power imbalances — and educators can help prevent this

    Source: The Conversation – Canada – By Deinera Exner-Cortens, Associate Professor of Psychology and Tier 2 Canada Research Chair (Childhood Health Promotion), University of Calgary

    Educators can help kids understand the difference between using power negatively and positively, and encourage its positive use to build respectful environments. (Allison Shelley/The Verbatim Agency for EDUimages), CC BY-NC

    Being at school among peers and friends can be exciting and positive for many children and youth. But, too many kids in Canada face the reality of being bullied because of some aspect of who they are.

    This type of bullying — known as identity-based or bias-based bullying — is extremely harmful to kids’ sense of belonging at school, and has negative effects on their physical and mental health, their academic achievement and their social well-being.

    As psychology researchers and directors of the Promoting Relationships and Eliminating Violence Network (PREVNet), we developed accessible learning modules for educators so they can learn to recognize identity-based bullying, and intervene to stop it.

    While explicitly developed with education settings in mind, these may also be helpful for parents or other caring adults in situations of influence for children’s peer relations. These modules will be available in French by the end of the year.

    Harmful to kids’ well-being

    Bullying has several key elements that make it so harmful to kids’ well-being.

    Bullying is unwanted, aggressive behaviour that is often repeated over time. These behaviours can be verbal, social, physical, sexual and/or cyber in nature.

    It happens in relationships where there is a power imbalance. In other words, the child who bullies holds more power than the child who experiences the bullying. In the case of identity-based bullying, this power imbalance is rooted in the types of power differences we see at a larger societal level.

    Bullying behaviours can be verbal, social, physical or sexual, and can take place in person or online.
    (Shutterstock)

    Social power dynamics, identity-based bullying

    It is well-documented that Indigenous youth, Black youth, 2SLGBTQIA+ youth and youth with disabilities experience discrimination in Canada.

    But why? Put simply, these experiences of discrimination are rooted in Canada’s settler-colonial history, which institutionalized racialized, class-based and colonial norms and forms of social privilege. These institutionalized forms of privilege resulted in greater political, social and economic power being granted to groups as they more closely aligned with these norms, with the greatest power allotted to those at the top of this “civilized” ideal: people who are white (western European), Christian, wealthy, cisgender, heterosexual, settler men.



    Read more:
    Rethinking masculinity: Teaching men how to love and be loved

    Groups who have been granted unearned power and privilege through these systems work to maintain their power through things like stigma, discrimination and other forms of oppression, while groups marginalized as “other” — less aligned with these dominant norms — continue to experience and hold less power across the socio-political-economic spectrum.

    And, youth who hold more than one socially marginalized identity often experience even greater discrimination.

    Schools as societal institutions

    Since schools are societal institutions, the discrimination and other forms of oppression that are used by dominant groups to maintain power in larger society are mirrored within schools through identity-based bullying.

    With identity-based bullying, the power imbalance that is a key feature of bullying behaviour is rooted in these larger social power imbalances.

    Because we all hold multiple social identities, a social power perspective also explains how these identities interact. Take, for example, a situation where a white, queer student is bullying a Black, queer student. Although both students are marginalized based on their queer identities, the white student still benefits from the power and privilege afforded to whiteness. So, this situation still reflects a power dynamic based on social identities.



    Read more:
    Racism contributes to poor attendance of Indigenous students in Alberta schools: New study

    Educator interventions

    Identity-based bullying is likely an issue in your neighbourhood school. In data we collected from 1,200 youth across Canada in 2023, one in three reported identity-based bullying because of their body weight, race or skin colour, disability, religion, sexual orientation and/or gender identity.

    Second, identity-based bullying impacts kids’ experiences at school. For example, a recent study from the United States found that youth who experienced multiple forms of identity-based bullying were the most likely to report avoiding class or activities. This study also found that if these same students felt more supported by adults at their school, they reported less school avoidance. This means caring educators are a protective factor for youth experiencing identity-based bullying.

    Our research has proposed ways educators specifically can prevent identity-based bullying in their schools:

    1) Educators (or other adults engaged in a school community) could examine their school board policy on bullying, and make sure it specifically mentions the role of social identities. If it doesn’t, educators can work to change it. A great example of naming identities when defining bullying can be seen in the Northwest Territories’ Education Act.

    2) Be self-reflective and aware. As a first step, educators can explore their own unconscious biases and reflect on how they may be influencing the classroom climate.

    3) Be a positive role model. Students look to adults about how to behave. Celebrate the strengths of all students and role model how to be respectful and inclusive. Also role model how to helpfully intervene when harmful behaviour occurs.

    4) Actively create opportunities for positive peer dynamics in the classroom. Be intentional about creating groups to ensure that students who are excluded are given the opportunity to interact and work with students who are kind and prosocial, and who may have similar interests and abilities.

    Educators can teach strategies that help all students learn how to be positive allies.
    (Shutterstock)

    5) Empower all students to intervene safely and effectively. Actively educate students on how to recognize identity-based bullying and provide strategies that will help all students to be positive allies.

    6) Work at classroom, school and community levels to create a welcoming, inclusive environment for all children. For educators, this can include things like conducting curriculum review, actively incorporating learning about power, privilege and oppression, creating and supporting clubs like gay-straight alliances and working to create a trauma-informed classroom.

    These strategies can be consolidated and deepened through engaging with our new anti-bullying training modules, which focus specifically on identity-based bullying.

    In these ways, educators and other caring adults can help kids understand the difference between using power negatively and positively, and encourage its positive use to build inclusive, respectful and safe environments for all.

    Deinera Exner-Cortens receives funding from the Public Health Agency of Canada and the Canada Research Chairs program. She is also the director of PREVNet Inc, a registered charitable organization in Canada.

    Elizabeth (Liz) Baker receives funding from the Public Health Agency of Canada and Alberta’s Children Services. She is affiliated with PREVNet as Executive Director.

    Wendy Craig receives funding from Public Health Agency of Canada. She is the Scientific Co-Director of PREVNet (Promoting Healthy Relationships and Eliminating Violence Network.

    – ref. Too many kids face bullying rooted in social power imbalances — and educators can help prevent this – https://theconversation.com/too-many-kids-face-bullying-rooted-in-social-power-imbalances-and-educators-can-help-prevent-this-237613

    MIL OSI – Global Reports –

  • MIL-OSI Global: What you need to know about cold and flu season

    Source: The Conversation – Canada – By Jennifer Guthrie, Assistant Professor of Microbiology and Immunology, Western University

    Flu shots are recommended for most Canadians over six months old. (Shutterstock)

    As the fall months settle in, Canadians are being urged to take precautions against the upcoming flu season.

    Flu season in Canada typically peaks between December and February, but the virus can circulate much earlier. Public health officials are advocating for early vaccination, emphasizing that the annual flu vaccine is the most effective way to protect against infection and reduce the severity of illness.

    Clinics across Canada offer flu shots free of charge.

    Influenza

    Influenza, commonly known as the flu, is a respiratory illness caused by influenza viruses that spread easily from person to person. These viruses mainly affect the nose, throat and lungs. Flu symptoms typically include fever, chills, muscle aches, cough, congestion, runny nose, headaches and fatigue.

    Unlike the common cold, which often develops slowly, the flu tends to hit suddenly and can lead to severe complications like pneumonia, bronchitis and even death, particularly in high-risk groups such as young children, seniors over 65, pregnant individuals, and those with chronic conditions like asthma, diabetes or heart disease.

    Influenza spreads mainly through droplets when an infected person coughs, sneezes or talks. These droplets can land in the mouths or noses of people nearby, or they can linger on surfaces where the virus can survive for up to 48 hours. Preventive measures such as handwashing, mask-wearing and staying home when symptomatic help reduce the spread of the virus.

    How the flu vaccine works

    Each year, flu vaccines are updated to protect against the influenza viruses that research indicates will be most common during the upcoming season. The flu shot contains inactivated or weakened influenza viruses, which cannot cause the flu but help the immune system develop antibodies. These antibodies protect against infection when exposed to live flu viruses.

    The vaccine typically takes about two weeks after administration for immunity to build up, which is why public health officials recommend getting vaccinated in the fall, before flu rates start to rise. This gives individuals enough time to develop immunity before influenza becomes more widespread.

    Can you get flu and COVID-19 vaccines together?

    Each year, flu vaccines are updated to protect against the influenza viruses that research indicates will be most common during the upcoming season.
    (Shutterstock)

    Public health experts have confirmed that it is safe to receive the flu vaccine and the COVID-19 vaccine at the same time. Doing so can provide protection against both illnesses and reduce the chances of severe complications from either virus. Administering both vaccines during the same visit is a convenient way to ensure you’re protected for the season, especially as COVID-19 continues to circulate alongside influenza.

    Benefits of the flu shot

    One of the key benefits of flu vaccination is that it significantly reduces the risk of severe illness, hospitalization and death from the flu. While flu vaccines aren’t 100 per cent effective at preventing infection, they greatly lessen the severity of the illness and reduce the spread of the virus in the community. This is especially important for protecting high-risk groups like seniors, children, pregnant people and individuals with chronic health conditions.

    Additionally, widespread flu vaccination helps prevent the health-care system from becoming overwhelmed, especially in a year when other respiratory viruses like respiratory syncytial virus (RSV) and COVID-19 are still circulating. By reducing the overall number of flu-related hospitalizations, vaccines also free up health-care resources for other urgent needs.

    Why get vaccinated every year?

    One of the unique challenges of influenza is that the virus mutates constantly. Because of these frequent changes, immunity from last year’s vaccine won’t provide full protection this season. This is why the flu vaccine is updated annually to match the most prevalent strains of the virus.

    Even if a person received a flu shot the previous year, it’s important to get vaccinated again to stay protected against new viral strains circulating in the population. Flu vaccines are reformulated each year based on global surveillance data collected by organizations like the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC).

    Misconceptions about the flu vaccine

    Despite clear benefits, misconceptions about the flu shot continue to contribute to low vaccination rates.

    Some people believe that the flu vaccine can cause the flu, but this is a myth. The inactivated viruses in the flu vaccine cannot cause illness. After receiving the vaccine, some people may experience mild side-effects like soreness at the injection site or a low-grade fever, but these symptoms are short-lived and far less severe than a full-blown flu infection.

    Another misconception is that the flu shot is not necessary for healthy adults. While healthy people may have a lower risk of severe flu complications, they can still spread the virus to more vulnerable individuals, such as young children, seniors or immunocompromised family members. Getting vaccinated helps protect both the individual and the community through herd immunity.

    Jennifer Guthrie does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

    – ref. What you need to know about cold and flu season – https://theconversation.com/what-you-need-to-know-about-cold-and-flu-season-240962

    MIL OSI – Global Reports –

  • MIL-OSI: Solomon Partners Hires James Butcher as Managing Director in the Technology Group

    Source: GlobeNewswire (MIL-OSI)

    NEW YORK, Oct. 14, 2024 (GLOBE NEWSWIRE) — Solomon Partners, a leading financial advisory firm and independent affiliate of Natixis, announced the appointment of James Butcher as a Managing Director in the Technology group. Based in New York, he will focus on advising companies in the Information Services and Business-to-Business (B2B) sectors and will further enhance Solomon’s Software, Data & Analytics coverage.

    Mr. Butcher joined Solomon from Moelis & Company, where he served as a Managing Director. During his 13-year tenure, he worked with clients in the Media & Technology sector, acting as a trusted advisor to large corporations and mid-market companies, as well as financial sponsors, on a variety of transactions.

    Craig Muir, who joined Solomon in 2023 to build out the Technology practice, noted that Mr. Butcher’s addition to the team expands the range of companies Solomon can serve in the sector.

    “James brings a wealth of experience and expertise in the Information Services and B2B sectors,” Mr. Muir said. “This will be invaluable as we continue to expand our capabilities and deliver exceptional service to our clients.”

    Mr. Butcher commented, “I am excited to be joining Solomon Partners and the Technology group, both of which have significant momentum. I have been impressed by the caliber of the bankers and the firm’s commitment to providing our clients with unrivaled advice and creative solutions. I am looking forward to working with Craig and the team to continue to grow the Technology group and to expand our coverage of the Information Services and B2B sectors.”

    Mr. Butcher earned a BA from University College London and is a Chartered Accountant (FCA).

    To learn more, read a Q&A with Solomon CEO Marc Cooper and Mr. Butcher here.

    About Solomon Partners

    Founded in 1989, Solomon Partners is a leading financial advisory firm with a legacy as one of the oldest independent investment banks. Our difference is unmatched industry knowledge in the sectors we cover, creating superior value with unrivaled wisdom for our clients. We advise clients on mergers, acquisitions, divestitures, restructurings, recapitalizations, capital markets solutions and activism defense across a range of industries. These include Business Services, Consumer Retail, Distribution, Financial Services & FinTech, Financial Sponsors, Healthcare, Grocery, Pharmacy & Restaurants, Industrials, Infrastructure, Power & Renewables, Media and Technology. Solomon Partners is an independently operated affiliate of Natixis, part of Groupe BPCE. For further information, visit solomonpartners.com.

    A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/202b978d-935b-4af9-b0b6-120821f1c595

    The MIL Network –

  • MIL-OSI Global: Evacuating in disasters like Hurricane Milton isn’t simple – there are reasons people stay in harm’s way

    Source: The Conversation – USA – By Carson MacPherson-Krutsky, Research Associate, Natural Hazards Center, University of Colorado Boulder

    Evacuation is more difficult for people with health and mobility issues. Ted Richardson/For The Washington Post via Getty Images

    As Hurricane Milton roared ashore near Sarasota, Florida, tens of thousands of people were in evacuation shelters. Hundreds of thousands more had fled coastal regions ahead of the storm, crowding highways headed north and south as their counties issued evacuation orders.

    But not everyone left, despite dire warnings about a hurricane that had been one of the strongest on record two days earlier.

    As Milton’s rain and storm surge flooded neighborhoods late on Oct. 9, 2024, 911 calls poured in. In Tampa’s Hillsborough County, more than 500 people had to be rescued, including residents of an assisted living community and families trapped in a flooding home after a tree crashed though the roof at the height of the storm.

    In Plant City, 20 miles inland from Tampa, at least 35 people had been rescued by dawn, City Manager Bill McDaniel said. While the storm wasn’t as extreme as feared, McDaniel said his city had flooded in places and to levels he had never seen. Traffic signals were out. Power lines and trees were down. The sewage plant had been inundated, affecting the public water supply.

    Evacuating might seem like the obvious move when a major hurricane is bearing down on your region, but that choice is not always as easy as it may seem.

    Evacuating from a hurricane requires money, planning, the ability to leave and, importantly, a belief that evacuating is better than staying put.

    I recently examined years of research on what motivates people to leave or seek shelter during hurricanes as part of a project with the Federal Emergency Management Agency and the Natural Hazards Center. I found three main reasons that people didn’t leave.

    Evacuating can be expensive

    Evacuating requires transportation, money, a place to stay, the ability to take off work days ahead of a storm and other resources that many people do not have.

    With 1 in 9 Americans facing poverty today, many have limited evacuation options. During Hurricane Katrina in 2005, for example, many residents did not own vehicles and couldn’t reach evacuation buses. That left them stranded in the face of a deadly hurricane. Nearly 1,400 people died in the storm, many of them in flooded homes.

    When millions of people are under evacuation orders, logistical issues also arise.

    Two days ahead of landfall, Milton was a Category 5 hurricane. About 5 million people were under evacuation orders, and highways were crowded.

    Gas shortages and traffic jams can leave people stranded on highways and unable to find shelter before the storm hits. This happened during Hurricane Floyd in 1999 as 2 million Floridians tried to evacuate.

    People who experienced past evacuations or saw news video of congested highways ahead of Hurricane Milton might not leave for fear of getting stuck.

    Health, pets and being physically able to leave

    The logistics of evacuating are even more challenging for people who are disabled or in nursing homes. Additionally, people who are incarcerated may have no choice in the matter – and the justice system may have few options for moving them.

    Evacuating nursing homes, people with disabilities or prison populations is complex. Many shelters are not set up to accommodate their needs. In one example during Hurricane Floyd, a disabled person arrived at a shelter, but the hallways were too narrow for their wheelchair, so they were restricted to a cot for the duration of their stay. Moving people whose health is fragile, and doing so under stressful conditions, can also worsen health problems, leaving nursing home staff to make difficult decisions.

    At least 700 people stayed in chairs or on air mattresses at River Ridge Middle/High School in New Port Richey, Fla., during Hurricane Milton.
    AP Photo/Mike Carlson

    But failing to evacuate can also be deadly. During Hurricane Irma in 2017, seven nursing home residents died in the rising heat after their facility lost power near Fort Lauderdale, Florida. In some cases, public water systems are shut down or become contaminated. And flooding can create several health hazards, including the risk of infectious diseases.

    In a study of 291 long-term care facilities in Florida, 81% sheltered residents in place during the 2004 hurricane season because they had limited transportation options and faced issues finding places for residents to go.

    Some shelters allow small pets, but many don’t. This high school-turned-shelter in New Port Richey, Fla., had 283 registered pets.
    AP Photo/Mike Carlson

    People with pets face another difficult choice – some choose to stay at home for fear of leaving their pet behind. Studies have found that pet owners are significantly less likely to evacuate than others because of difficulties transporting pets and finding shelters that will take them. In destructive storms, it can be days to weeks before people can return home.

    Risk perception can also get in the way

    People’s perceptions of risk can also prevent them from leaving.

    A series of studies show that women and minorities take hurricane risks more seriously than other groups and are more likely to evacuate or go to shelters. One study found that women are almost twice as likely than men to evacuate when given a mandatory evacuation order.

    If people have experienced a hurricane before that didn’t do significant damage, they may perceive the risks of a coming storm to be lower and not leave.

    Video from across Florida after Hurricane Milton shows flooding around homes, trees down and other damage. At least 12 people died in the storm, and more than 3 million homes lost power.

    In my review of research, I found that many people who didn’t evacuate had reservations about going to shelters and preferred to stay home or with family or friends. Shelter conditions were sometimes poor, overcrowded or lacked privacy.

    People had fears about safety and whether shelter environments could meet their needs. For example, religious minorities were not sure whether shelters would be clean, safe, have private places for religious practice, and food options consistent with faith practices. Diabetics and people with young children also had concerns about finding appropriate food in shelters.

    How to improve evacuations for the future

    There are ways leaders can reduce the barriers to evacuation and shelter use. For example:

    • Building more shelters able to withstand hurricane force winds can create safe havens for people without transportation or who are unable to leave their jobs in time to evacuate.

    • Arranging more shelters and transportation able to accommodate people with disabilities and those with special needs, such as nursing home residents, can help protect vulnerable populations.

    • Opening shelters to accommodate pets with their owners can also increase the likelihood that pet owners will evacuate.

    • Public education can be improved so people know their options. Clearer risk communication on how these storms are different than past ones and what people are likely to experience can also help people make informed decisions.

    • Being prepared saves lives. Many areas would benefit from better advance planning that takes into account the needs of large, diverse populations and can ensure populations have ways to evacuate to safety.

    This article has been updated with additional details about Hurricane Milton’s damage.

    Carson MacPherson-Krutsky works for the Natural Hazards Center (NHC) at the University of Colorado Boulder. She receives grant and contract funding for her work at NHC through the National Science Foundation, the U.S. Army Corps of Engineers, the Federal Emergency Management Agency, and other funders.

    – ref. Evacuating in disasters like Hurricane Milton isn’t simple – there are reasons people stay in harm’s way – https://theconversation.com/evacuating-in-disasters-like-hurricane-milton-isnt-simple-there-are-reasons-people-stay-in-harms-way-240869

    MIL OSI – Global Reports –

  • MIL-OSI USA: Helping Older New Yorkers Save in Health Care Costs

    Source: US State of New York

    Governor Kathy Hochul today announced that nearly one million New Yorkers are now enrolled in State-administered Medicare Savings Program (MSP), which can help eligible older adults save an estimated average of $7,400 per year in health care costs. With the Medicare open enrollment period starting tomorrow, Governor Hochul also encouraged more New Yorkers to learn about and enroll in the MSP. Many older adults are eligible for this program following the Governor’s historic expansion of the MSP, which increased income eligibility limits to ensure more New Yorkers can benefit from health care savings.

    “Our work to expand the Medicare Savings Program is helping ease the burden of healthcare costs for nearly one million New Yorkers and putting thousands of dollars back in their pockets,” said Governor Kathy Hochul. “I encourage older adults in New York to use the Medicare open enrollment period to find out if they are eligible for the program and to learn if other Medicare coverage options can provide additional cost savings.”

    The Medicare open enrollment period begins tomorrow, Oct. 15, and will remain open until Dec. 7. While New Yorkers can enroll in the MSP all year round, the open enrollment period is a great time to learn about the benefits and address any Medicare questions.

    The MSP helps Medicare beneficiaries living on limited incomes by paying their Medicare Part B premiums and automatically enrolling them in the federal government’s Extra Help program, which helps with prescription drug costs.

    In 2022, Governor Hochul secured an historic expansion of the MSP that increased income eligibility limits for New Yorkers. The 2024 income eligibility limits for the MSP are $2,355 per month for an individual and $3,189 per month for a couple.

    Medicare beneficiaries or Medicare-eligible individuals are encouraged to contact the state’s Health Insurance Information, Counseling and Assistance Program (HIICAP) for information on enrolling in the MSP or to receive assistance with other Medicare enrollment questions. New Yorkers can call the HIICAP toll-free hotline at 1-800-701-0501.

    Below is a regional breakdown of the nearly one million New Yorkers already enrolled in the MSP as of late Sept.

    REDC Region Number of MSP Enrollees

    Western New York

    Allegany, Cattaraugus, Chautauqua, Erie, Niagara

    		 62,004

    Finger Lakes

    Genesee, Livingston, Monroe, Ontario, Orleans, Seneca, Wayne, Wyoming, Yates

    		 49,062

    Southern Tier

    Broome, Chemung, Chenango, Delaware, Schuyler, Steuben, Tioga, Tompkins

    		 30,340

    Central New York

    Cayuga, Cortland, Madison, Onondaga, Oswego

    		 30,409

    Mohawk Valley

    Fulton, Herkimer, Montgomery, Oneida, Otsego, Schoharie

    		 24,673

    North Country

    Clinton, Essex, Franklin, Hamilton, Jefferson, Lewis, St. Lawrence

    		 20,973

    Capital District

    Albany, Columbia, Greene, Rensselaer, Saratoga, Schenectady, Warren, Washington

    		 39,803

    Hudson Valley

    Dutchess, Orange, Putnam, Rockland, Sullivan, Ulster, Westchester

    		 71,200
    New York City 574,665

    Long Island

    Nassau, Suffolk

    		 79,863
    Statewide Total 982,992

    New York State Office for the Aging Director Greg Olsen said, “This important milestone – nearly 1 million individuals enrolled in the MSP – is a direct result of state and local programs like New York HIICAP providing outreach and assistance for Medicare beneficiaries so that they can collectively save millions of dollars annually on out-of-pocket expenses. I applaud Governor Hochul for expanding this program in 2023, with annual income eligibility updates each year, and for supporting our network’s outreach and education activities to help.”

    New York State Department of Health Commissioner Dr. James McDonald said, “The Medicare Savings Program is a vital resource to assist people with limited income in paying their Medicare premiums and individuals who may not qualify for Medicaid because of income limits can still qualify for this savings program. That enrollment has reached close to one million individuals highlights the ongoing commitment to health equity by Governor Hochul and the Department, by ensuring those who need financial help can access timely medical care at an affordable cost.”

    AARP New York State Director Beth Finkel said, “AARP New York worked for years with other advocates to expand the Medicare Savings Program so more low- and moderate-income older adults could afford essential health care. Now, enrollment in the program is approaching the one million mark – something all of us can be proud of. We applaud the Hochul administration for its ongoing efforts to ensure more older New Yorkers have access to the benefits they need, benefits that put money back in their pockets and alleviate financial burdens. We want people to have better lives, and this program was created to do just that.”

    President of the Medicare Rights Center Fred Riccardi said, “New York’s successful expansion of the Medicare Savings Program is a testament to the importance of collaboration to ensure older adults and people with disabilities can access and afford the health care they deserve. We commend the New York State Office for the Aging, New York State Department of Health, and our partners across the state. Our collective efforts and dedication have been vital in expanding access to this crucial program, ensuring more New Yorkers can experience the financial relief and enhanced health care access it provides. The Medicare Rights Center is proud of this milestone and wholeheartedly committed to helping thousands more navigate the enrollment process and secure the benefits they are entitled to.”

    More About the MSP

    The MSP helps Medicare beneficiaries living on limited incomes by paying their Medicare Part B premiums and automatically enrolls them in Extra Help. The U.S. Social Security Administration (SSA) estimates a potential cost savings of $5,300 per person enrolled in Extra Help. The standard monthly premium for Medicare Part B enrollees is$174.70 per month. Combined this assistance equals nearly $7,400 in savings annually. This financial assistance can be a lifeline for enrollees, allowing them to maintain their Medicare coverage, access needed care, and afford other necessities.

    In 2022, Governor Hochul announced an historic expansion of the MSP, which is administered at the state level. The 2024 income eligibility limits for the MSP are $2,355 per month for an individual and $3,189per month for a couple.

    Beneficiaries with income just above the posted limits should still consider contacting New York HIICAP for assistance in the application process, as individuals may be paying for out-of-pocket costs that can be deducted from their gross income to make them eligible. HIICAP offers free and objective counseling for Medicare beneficiaries needing assistance applying for the MSP or any other Medicare-related questions. Simply call HIICAP at 1-800-701-0501. Callers will be routed to their local program for assistance.

    An application for the MSP is also available on the New York State Department of Health website here . The application and required documentation should be sent your local Department of Social Services (LDSS) or Human Resource Administration (HRA). Find the address in your county here. To apply, applicants will need photocopies of their Medicare card, proof of income, documentation about health insurance premiums other than Medicare, proof of date of birth and residence. Learn more on NYSOFA’s website.

    About Medicare Open Enrollment

    Open enrollment is the time when Medicare beneficiaries can make changes in their health plan or prescription drug coverage and other options.

    During open enrollment, or at any time of the year, HIICAP can help you:

    • Understand the Medicare prescription drug benefit (Medicare Part D) and how to select the best plan.
    • Understand low-income subsidy programs, including Extra Help and Medicare Savings Programs (MSPs).
    • Find ways to pay for your medications or medical equipment.
    • Understand and apply for the Elderly Pharmaceutical Insurance Coverage (EPIC) program.
    • Choose between original Medicare and Medicare Advantage plans.
    • Understand Medicare rules and your medical bills.
    • Report possible Medicare fraud or abuse.
    • Provide information on how to appeal a decision by Medicare, your managed care provider or other health insurance company.
    • Discover ways to fill in Medicare’s gaps.
    • Learn how to file a Medicare or Medigap complaint.

    MIL OSI USA News –

  • MIL-OSI United Kingdom: Chancellor announces new plans to secure UK investment

    Source: United Kingdom – Executive Government & Departments

    The Chancellor closes the International Investment Summit promising the government is bringing investment and jobs back to Britain.

    In a speech to some of the world’s biggest businesses and investors, Rachel Reeves revealed that restoring fiscal stability will be at the centre of her first Budget on 30 October. She made the case that it is the only way to ensure government and business can invest with confidence. 

    The Chancellor went on to set out how two new bodies will drive long-term investment in Britain as the government works hand in hand with business to create new high skilled jobs right across the UK, helping make people better off. 

    Chancellor of the Exchequer Rachel Reeves, MP said: 

    When we said we would end instability, make growth our national mission and enter a true partnership with business we meant it.  

    The decisions which lie ahead of us will not always be easy. But by taking the right choices to grow our economy and drive investment we will create good jobs and new opportunities across every part of the country. That is the Britain we are building. 

    The first announcement from the Chancellor was that from today the UK Infrastructure Bank will operate as the National Wealth Fund (NWF), with its headquarters in Leeds. 

    The National Wealth Fund will catalyse tens of billions of pounds of private investment into in the UK’s clean energy and growth industries, including green hydrogen, carbon capture and gigafactories.

    Building on UKIB’s leadership and expertise, the NWF will go further, able to make investments that maximise the mobilisation of private investment. This will include the ability to trial new blended finance solutions with government departments that take on additional risk to facilitate higher impact in individual deals and performance guarantees. 

    The National Wealth Fund will have a total of £27.8 billion and will work with key industry partners, including mayors, to support delivery of their investment plans. 

    The Government will also bring forward legislation to give the NWF a broader mandate than just infrastructure, ensuring it is a permanent part of government’s investment offer. 

    John Flint, CEO, at the National Wealth Fund said: 

    It is a huge privilege to be entrusted with the responsibility of leading the National Wealth Fund. Building on the strong foundations we have laid as UKIB, we will hit the ground running, using sector insight and investment expertise that the market knows and trusts to unlock billions of pounds of private finance for projects across the UK.

    With additional capital to deploy against a bigger mandate, we stand ready to help the market invest with confidence, in support of the Government’s growth ambitions.

    Alongside this the Chancellor, together with Secretary of State for Business and Trade Jonathan Reynolds, announced a new British Growth Partnership as part of the British Business Bank (BBB). 

    The BBB already supports the UK’s fastest growing, most innovative companies deploying £3.5bn to support over 23,000 businesses last year. 

    The British Growth Partnership will allow it to do more by creating a new way for the British Business Bank and institutional investors to invest in innovative companies together.

    Leveraging the British Business Bank’s market expertise, these long-term investments will be made independently of government on a fully commercial basis. In the coming months, the British Business Bank will seek to raise hundreds of millions of pounds of investment for this fund, with the aim of making investments by the end of 2025.

    Additionally, the government will implement a set of reforms to the British Business Bank’s financial framework that will increase its impact and increase its ability to respond flexibly to the market, including by putting the British Business Bank’s £7.9bn set of commercial programmes on a permanent footing.

    Louis Taylor, CEO, British Business Bank said:

    Today’s announcement is a strong endorsement of the British Business Bank’s 10-year track record, market access and capabilities. By establishing the British Growth Partnership, the Bank will encourage more UK pension fund investment into the UK’s fastest growing, most innovative companies. 

    In addition, reforms to the Bank’s financial framework, putting our £7.9bn commercial programmes on a permanent footing, means we can flexibly re-invest our investment returns over the long term to increase growth and prosperity across the UK.

    Today’s measures follow the Government announcing more than £24 billion of private investment for pioneering energy projects and thousands of jobs in the green industries secured ahead of International Investment Summit.

    This adds to the announcement last week that up to 500 UK manufacturing jobs are set to be supported as bus operator Go Ahead confirms a major £500 million investment to decarbonise its fleet. This includes creating a new dedicated manufacturing line and partnership with Northern Ireland-based UK bus manufacturer Wrightbus.    

    And it also builds on the Government confirming funding to launch the UK’s first carbon capture sites in Teesside and Merseyside. Two new carbon capture and CCUS enabled hydrogen projects will create 4,000 new jobs, in a boost for the economy and British industry, helping remove over 8.5 million tonnes of carbon emissions each year – the equivalent of taking around 4 million cars off the road.    

    Further quotes:

    Dame Julia Hoggett, CEO, London Stock Exchange Plc said:

    It is critically important for the growth of the UK economy that home grown companies are able to access the investment they need to grow, scale and stay in the UK. 

    Access to meaningful UK capital at the scaling phase has been a long-recognised challenge and so we are delighted that British Growth Partnership is being established to help address this problem. This will also facilitate more investment by UK pension schemes into scaling UK companies, providing greater returns for their savers and giving UK investors a greater stake in the UK economy.

    Sir Nicholas Lyons, Group Chair, Phoenix said:

    The UK needs scale and skills to convert our brilliant science and technology start-ups and university spinouts into the successful and sustainable companies of tomorrow.  British Growth Partnership will complement the private sector DC pension industry’s undertakings under the Mansion House Compact to expedite this, directing investment to deliver the best returns for our pension savers.

    Professor Sir John Bell, President, Ellison Institute of Technology said:

    Making sure the best innovative British companies can access the capital they need to scale and stay in the UK is critical for the future of the economy. The Chancellor’s announcement today of the new British Growth Partnership, in addition to confirming £7.9bn of permanent capital for the British Business Bank, are both very welcome and significant steps forward in solving this problem

    Sir Jonathan Symonds CBE, Non-Executive Chair, GSK said:

    This is a welcome step; encouraging institutional investment into the UK’s high-growth-potential companies can provide a real boost to the economy and generate better returns for individuals’ pension investments

    Brent Hoberman, Chairman and Co-Founder, Founders Forum Group, Founders Factory, firstminute capital said:

    It’s great to see the new government taking concrete steps to amplify the Mansion House reforms.   This new British Growth Partnership should help UK startups access further scale up capital to create more world leaders.

    Saul Klein, Co-founder, Phoenix Court and Member of the Council for Science and Technology said:

    The UK has more than 750 venture backed companies generating more than $25m in revenue – this is more than France, Germany, Sweden and the Netherlands combined. These companies have created over 200,000 new jobs and continue to grow but the UK still has $35bn less scale up capital to support these companies than the United States’ Bay Area alone.

    The government’s continued support for the British Business Bank and its focus on addressing this scale up opportunity will be very much welcomed by these 750 companies as well as the cohorts coming behind them.

    Peter Harrison, Group Chief Executive, Schroders plc said:

    These are further helpful initiatives in creating an environment where risk capital can flow into strategically important industries. Every step is welcome in supporting future economic growth.

    Edward Braham, Chairman, M&G said:

    We welcome the creation of the British Growth Partnership which should unlock much needed investment into the UK’s high growth innovative businesses.

    The combination of private and public sector partnerships, underpinned by long term patient capital, is essential to create the conditions for sustainable growth. 

    As a leading international investor, M&G has a proud history of supporting the progress of businesses and communities across the UK, investing in new innovative companies and private assets such as housing, hospitals and transport.

    Steve Bates OBE, CEO of the BioIndustry Association, said:

    Our world-leading, innovative life sciences and biotech sector is a unique competitive advantage for economic growth. The sector attracts expert global investors but a lack of investment from UK-based institutional investors means the economic and social returns are too often lost overseas.

    The British Growth Partnership will help turbo-charge innovative businesses with fresh UK-based capital, enabling them to scale in the UK and deliver more returns to the British economy, and to ordinary people saving for their retirement. This is a win-win-win for UK life science businesses, for UK pension savers and for the forward-thinking financial services sector.

    Kate Bingham, Managing Partner, SV Health and Former Chair UK Vaccine Taskforce welcomed the announcements saying:

    The UK has the potential to be a global leader and hub for healthcare breakthroughs with its strong entrepreneurial and academic base, together with our expertise and innovation in data science and artificial intelligence.

    Making the British Business Bank independent of government as well as launching the British Growth Partnership enables the Bank to catalyse institutional investment, including from pension funds, into brilliant UK companies that are supercharging the development of revolutionary medical treatments including smarter medicines for cancer, Alzheimer’s and blindness.

    Dom Hallas, Executive Director, Startup Coalition said:

    Tech startups and scaleups need a stable and improving funding environment to compete globally. The British Business Bank’s role in helping create that landscape is critical and today’s announcement will help the UK continue to build VC-backed tech companies across the country that are ready to compete with the very best.

    Michael Moore, Chief Executive, BVCA said:

    It is extremely welcome that the Government and the British Business Bank have brought this hugely significant programme forwards so quickly.

    The prize is to get significant new capital into the growth equity and venture capital funds that are creating new industries and backing innovative businesses that will be the backbone of the British economy of tomorrow. The British Business Bank has a vital role catalysing institutional investment into fast growing British businesses and this announcement will boost that work substantially.

    Just 3% of the pensions investment into UK led growth equity and venture capital funds is from UK pension funds. Alongside the Government’s pensions review this major new vehicle can be the start of a major shift that sees UK pensions savers get the improved retirement income that can come from backing funds which deliver active ownership and long-term investment in business.

    Kerry Baldwin, Co-Founder, Managing Partner, IQ Capital said:

    The launch of the British Growth Partnership and the confirmation of a permanent capital allocation for the British Business Bank are two crucial steps forward in solving the lack of access to domestic capital for the UK’s most promising growth companies.

    I very much welcome the Chancellor’s announcement today, she has been hugely engaged with the venture capital and technology sector, and champions the incredible societal impact that our sector enables through investments into innovative technologies across the UK.

    The British Business Bank has been at the heart of powering the next generation of UK venture and growth funds and the launch of the new fund is welcome as part of the pension reforms.  This fund will enable access to world-leading science and innovative investments which increase productivity by transforming legacy industries through the adoption of novel technologies and also by providing growth capital to the next generation of globally leading frontier technologies which are solving pressing critical global issues from climate change to energy transition.

    Dr Andrew Williamson, Managing Partner, Cambridge Innovation Capital, and member of BVCA Council said:

    Since its formation in 2018, British Patient Capital has played a central role in the growth of the UK’s knowledge-intensive innovation ecosystem.  It has built a world leading team and investment platform with a strong track record of investing in UK deeptech and life sciences companies and the venture capital funds that support these companies. 

    The British Growth Partnership will make the Bank’s extensive expertise available to a broader range of institutional investors, providing attractive returns for those investors and increasing the capital available for leading UK start-up and scale-up businesses.

    Duncan Johnson, Chief Executive Officer, Northern Gritstone said:

    We at Northern Gritstone believe that skilled partnerships that channel patient investment into long-term growth and innovation are more important than ever for the UK. 

    By establishing the British Growth Partnership, the British Business Bank is creating a pathway for pension funds and institutional investors to support the future today. Through investment we can create and scale the world class businesses of tomorrow in the UK which is the platform for growth for our economy over the decades to come.

    Irene Graham OBE, CEO, ScaleUp Institute said:

    The ScaleUp Institute has long evidenced the important role of development banks and Sovereign Wealth Funds to global scaleup economies.  The Government’s  placement of the British Business Bank commercial initiatives into permanency, with greater  flexibility, alongside the creation of the great British Growth Partnership are very much welcome and represent significant milestones for the UK economy. 

    Alongside a National Wealth Fund these entities and commitments should further address structural, regional and sectoral disparities and ensure our innovative scaling businesses across the country are better connected, at all stages of growth, to the vital patient capital and institutional funds to enable their global scale and continue to foster our international competitiveness.

    Lisa Quest, Managing Partner UK and Ireland, Oliver Wyman:

    Today’s announcement is a significant milestone for the UK economy. The National Wealth Fund will increase investment across key sectors and accelerate the UK’s clean energy transition. I look forward to the many contributions this initiative will unlock for years to come.

    Dr Rhian-Mari Thomas, Chair of the Taskforce and CEO of the Green Finance Institute said:

    The NWF creates an opportunity for simplification and scale. The challenge now is to ensure it delivers private capital at the pace we need, through innovative risk-sharing transactions in new technologies.

    On top of today’s announcements, the government expects both successful bidders of the Long-Term Investment for Technology and Science (LIFTS) competition, Schroders and ICG, to begin making investments via their new funds in late 2024. Supported by pensions capital from Phoenix Group, the aim is to generate over a billion pounds of investment into UK science and technology companies.

    Updates to this page

    Published 14 October 2024

    MIL OSI United Kingdom –

  • MIL-OSI Asia-Pac: CSTB holds interdepartmental meeting in response to the death of animals in HKZBG

    Source: Hong Kong Government special administrative region

    CSTB holds interdepartmental meeting in response to the death of animals in HKZBG
    CSTB holds interdepartmental meeting in response to the death of animals in HKZBG
    *********************************************************************************

         ​In view of the death of eight animals in Hong Kong Zoological and Botanical Gardens (HKZBG) yesterday (October 13), the Secretary for Culture, Sports and Tourism, Mr Kevin Yeung, convened an urgent interdepartmental meeting today (October 14) to listen to reports on the latest situation by the Leisure and Cultural Services Department, the Agriculture, Fisheries and Conservation Department as well as the Department of Health, and to discuss the way forward.     The meeting noted that the park staff have immediately stepped up monitoring of the conditions of all animals since yesterday. The movement response and appetite of a White-faced Saki and a De Brazza’s Monkey were found unusual and they were removed from the original animal cages for close monitoring. The White-faced Saki has passed away this morning. The Park will continue to observe its status of the remaining De Brazza’s Monkey.     The Mammals Section of the HKZBG has been temporarily closed from this morning to facilitate the close monitoring of the conditions of those animals. The disinfection and cleaning of animal cages involved were completed. The health condition of all 80 animals in the HKZBG are normal. For the sake of prudence, staff working there will wear appropriate protective gear and keep a close watch on their health condition. At present, all staff is in healthy condition.     In addition, the meeting discussed the different scenarios of case development and solutions. Relevant government departments will speed up autopsy and toxicological testing by relevant departments, so that the possible causes of the incident could be known as soon as possible.

     
    Ends/Monday, October 14, 2024Issued at HKT 23:12

    NNNN

    MIL OSI Asia Pacific News –

  • MIL-OSI Asia-Pac: Appeal for information on wandering man in Castle Peak (with photo)

    Source: Hong Kong Government special administrative region

         Police are eager to locate the next-of-kin of a man who was found wandering in Castle Peak today (October 14).

         At about 6pm, Police received a report that a man was found wandering at a bus stop on Wu Chui Road.

         The man is about 25 years old. He is about 1.8 metres tall and of thin build. He has a pointed face with yellow complexion and short black hair. He wore a pair of black glasses, a brown short-sleeved shirt, black trousers and grey sports shoes. No identity document was found.

         The man, sustaining no superficial injuries, was sent to Tuen Mun Hospital for check-up.

         Police urge his relatives or anyone who has information, to contact any police station or the officers of Castle Peak Division on 3661 5900 or 3661 5925 or email to do-rr-4-cpkdiv@police.gov.hk.   

    MIL OSI Asia Pacific News –

  • MIL-OSI: AGBA TAKES FINAL STEP TOWARD COMPLETION OF TRILLER MERGER

    Source: GlobeNewswire (MIL-OSI)

    The previously announced reverse stock split to comply with Nasdaq’s rules in connection with the merger will take effect on October 15, 2024.

    NEW YORK, NY / LOS ANGELES, CA , Oct. 14, 2024 (GLOBE NEWSWIRE) —  AGBA Group Holding Limited (Nasdaq: AGBA) (“AGBA” or the “Company”) and Triller Corp. (“Triller”) today announced that Nasdaq approval for their merger was received on October 11, 2024. The merger is now expected to be completed on October 15, 2024.

    This merger represents the next step in AGBA and Triller’s collective strategic visions in the digital economy. The combination of AGBA and Triller will accelerate innovation, clear a path towards rapid growth and expand the combined company’s market presence globally, creating unparalleled value for all stakeholders of the company.

    The 1-for-4 reverse stock split is implemented in order to remain in compliance with Nasdaq’s rules in connection with the merger with Triller Corp. (“Triller”). The combined company’s shares will commence trading on a split-adjusted basis on October 16, 2024.

    About AGBA   

    Established in 1993, AGBA Group Holding Limited (Nasdaq: “AGBA”) is a leading, multi-channel business platform that incorporates cutting edge machine-learning and offers a broad set of financial services and healthcare products to consumers through a tech-led ecosystem, enabling clients to unlock the choices that best suit their needs. Trusted by over 400,000 individual and corporate customers, the Group is organized into four market-leading businesses: Platform Business, Distribution Business, Healthcare Business, and Fintech Business.

    For more information, please visit http://www.agba.com.

    About Triller Corp.     
    Triller Corp. is a next generation, AI-powered, social media and live-streaming event platform for creators. Pairing music culture with sports, fashion, entertainment, and influencers through a 360-degree view of content and technology, Triller Corp. uses proprietary AI technology to push and track content virally to affiliated and non-affiliated sites and networks, enabling them to reach millions of additional users. Triller Corp. additionally owns Triller Sports, Bare-Knuckle Fighting Championship (BKFC); Amplify.ai, a leading machine-learning, AI platform; and TrillerTV, a premier global PPV, AVOD, and SVOD streaming service.

    For more information, visit http://www.triller.co.

    Investor Relations:     
    Bethany Lai
    ir@agba.com

    Safe Harbor Statement
    This press release contains forward-looking statements as defined by the Private Securities Litigation Reform Act of 1995. Forward-looking statements include statements concerning plans, objectives, goals, strategies, future events or performance, and underlying assumptions and other statements that are other than statements of historical facts. When the Company uses words such as “may,” “will,” “intend,” “should,” “believe,” “expect,” “anticipate,” “project,” “estimate” or similar expressions that do not relate solely to historical matters, it is making forward-looking statements. Forward-looking statements are not guarantees of future performance and involve risks and uncertainties that may cause the actual results to differ materially from the Company’s expectations discussed in the forward-looking statements. These statements are subject to uncertainties and risks including, but not limited to, the following: the closing of the merger; the expected date of the merger; the market effective date of the Company’s actions; the Company’s goals and strategies; the Company’s future business development; product and service demand and acceptance; changes in technology; economic conditions; the outcome of any legal proceedings that may be instituted against us following the consummation of the business combination; expectations regarding its strategies and future financial performance, including its future business plans or objectives, prospective performance and opportunities and competitors, revenues, products, pricing, operating expenses, market trends, liquidity, cash flows and uses of cash, capital expenditures, and its ability to invest in growth initiatives and pursue acquisition opportunities; reputation and brand; the impact of competition and pricing; government regulations; fluctuations in general economic and business conditions in Hong Kong and the international markets the Company plans to serve and assumptions underlying or related to any of the foregoing and other risks contained in reports filed by the Company with the SEC, the length and severity of the recent coronavirus outbreak, including its impacts across its business and operations. For these reasons, among others, investors are cautioned not to place undue reliance upon any forward-looking statements in this press release. Additional factors are discussed in the Company’s filings with the SEC, which are available for review at http://www.sec.gov. The Company undertakes no obligation to publicly revise these forward–looking statements to reflect events or circumstances that arise after the date hereof.

    # # #

    The MIL Network –

  • MIL-OSI United Kingdom: Record-breaking International Investment Summit secures £63 billion and nearly 38,000 jobs for the UK

    Source: United Kingdom – Executive Government & Departments

    Nearly 38,000 UK jobs are set to be created across the UK after a total of £63 billion of investment was announced around today’s International Investment Summit.

    • Total of £63 billion of private investment committed around International Investment Summit, more than doubling amount secured at 2023 Global Investment Summit
    • New investments today include £6.3 billion in UK data centres as well as world class UK university Imperial College London
    • Innovative investment projects announced over the last month across infrastructure, renewables and life sciences will create close to 38,000 new jobs across the UK

    Nearly 38,000 UK jobs are set to be created across the UK after a total of £63 billion of investment was announced around today’s International Investment Summit, turbocharging growth and innovation across the country. 

    The record-breaking total figure more than doubles the £29.5 billion committed at last year’s Global Investment Summit and spans partnerships across the infrastructure and tech sectors, including over a billion pounds in new investments announced today by DP World, Associated British Ports (ABP) and Imperial College London. 

    Through serious, stable governance, the UK is attracting tens of billions of pounds of new investment which is crucial to the government’s driving mission of delivering economic growth. Today’s historic figure demonstrates that businesses have confidence in Britain as a place to invest. 

    The investments follow immediate action taken by the new government to reform planning, focus on AI and data centre expansion, and set a clear commitment to net zero by almost doubling the funding for renewable energy projects. 

    Four major tech firms based in the US have today announced £6.3 billion in UK data centres which is critical to enhancing the UK’s AI capacity – in turn fuelling Britain’s economic growth and spurring on AI development. Data centres store the vast amount of information and data needed to power AI, and store the information generated by AI to keep the systems running. 

    ABP, the UK’s largest port operator, has committed over £200 million to a joint investment with ferry company Stena Line in a new freight ferry terminal at the Port of Immingham, significantly boosting the capacity and resilience of UK trade with Europe. It is expected to create around 700 jobs during construction and around 200 permanent jobs once operational. 

    Leading UK university Imperial College London is also today announcing a £150 million investment to secure a new R&D campus to add to its rapidly expanding deep tech ecosystem in West London. The new campus will expand scale-up capacity in the WestTech Corridor, supporting the UK’s innovation sector and driving investment, economic growth and job creation. 

    Business and Trade Secretary Jonathan Reynolds said:

    Global investors should be in no doubt that under this new government Britain is truly the best place to do business. The record-breaking investment total secured at today’s Summit marks a major vote of confidence in the UK and our stability dividend across industry and innovation.

    We’re determined to deliver economic growth in every part of the UK and these investments, together with our forthcoming Industrial Strategy, will give global businesses the certainty they need as we lead the charge for the innovation and jobs of the future.

    Chancellor of the Exchequer Rachel Reeves said:

    After the investments secured as part of this summit, my optimism for Britain burns brighter than ever. It’s a sign of the confidence in the British economy. And it matters because it will support the growth of businesses big and small across the U.K. Helping them create new jobs and making people better off.

    CEO of ABP Henrik L. Pedersen said:

    We are delighted that the Development Consent Order (DCO) for the Immingham Eastern Ro-Ro Terminal (IERRT) has been granted in a timely way by the Secretary of State to allow us to move forward with investment. The IERRT project is a key component of our strategy to strengthen the UK’s supply chains and improve trade connectivity, whilst also bringing substantial economic benefits including the creation of hundreds of jobs during construction and ongoing operations. IERRT forms part of the intended £5.5bn pipeline of UK investment we have in front of us over the next 10 years and we look forward to working closely with the Government to deliver the right conditions to realise this investment.

    President of Imperial College London Hugh Brady said:

    Imperial College London is investing in its ambitious vision for a new globally competitive deep tech innovation ecosystem in West London. The Imperial WestTech Corridor will act as a powerful engine for investment, inclusive economic growth, and job creation at a local, regional, and national level supported by the Government’s emerging Industrial Strategy.

    Please see below for a list of all the investments announced in the run-up to and during today’s International Investment Summit:

    • Iberdrola doubling their investment in the UK, through Scottish Power, from £12 billion to £24 billion over the next 4 years. This includes £4 billion for the East Anglia 2 wind farm off the Suffolk coast which was unlocked by this Government’s expanded allocation at the most recent wind auction round. Iberdrola Executive Chairman Ignacio Galan CBE confirmed on Friday that the UK has become their largest Investment destination. 

    • Blackstone confirmed a £10 billion investment in Blyth, Northumberland to create one of the largest artificial data centres in Europe, creating 4,000 jobs, including 1,200 roles dedicated to the construction of the site. 

    • Amazon Web Services announced an £8 billion investment last month which is estimated to support around 14,000 jobs per year at local businesses, including those across the company’s data centre supply chain such as construction, facility, maintenance, engineering and telecommunications. 

    • CCUS investors (including Eni, BP and Equinor) reached a commercial agreement with the government that will unlock £8 billion of private investment to launch carbon capture clusters in the heartlands of the North West and North East of England, directly creating 4,000 jobs and supporting 50,000 jobs in the long-term. 

    • Orsted and Greenvolt confirming that the Government’s recent expanded offshore wind auction means their projects will unlock £8 billion (Orsted) and £2.5 billion (Greenvolt) of investment respectively in their planned offshore wind farms. Orsted says its commitment will see thousands of jobs for local people, while Greenvolt says it will create up to 2800 construction jobs.  

    • CyrusOne, a leading global data centre developer headquartered in the United States, announced plans to expand their investment into the UK to £2.5 billion over the coming years. Subject to planning permission, the two data centres should be operational by Q4 2028, projected to create over 1,000 jobs both directly and within its immediate design and construction value chain.   

    • Octopus Energy have committed to a £2 billion investment in renewable energy generation, including four new solar farms in Bristol, Essex, East Riding of Yorkshire and Wiltshire that will power up to 80,000 homes as well as breaking ground on a new 12 MW battery in Cheshire which Octopus say will store enough power for nearly 10,000 homes every day. 

    • SeAH Wind has made an additional £225 million investment into wind technology manufacturing in Teesside, thanks to new backing from UK Export Finance, and expects to create 750 direct jobs by 2027. This brings their total investment into the site at Teesworks up to £900 million and will help them make their ongoing factory build – one of the biggest facilities of its kind worldwide – even bigger. 

    • CloudHQ is developing its new state-of-the-art £1.9 billion data centre campus in Didcot. The hyper-scale data centre is currently in development and will help meet the UK’s growing demand for AI and machine learning. It will create 1,500 jobs during construction, and 100 permanent jobs once fully operational.  

    • Macquarie supporting investment of £1.3 billion into new green infrastructure including its Island Green Power solar farm in Stow, as a result of planning consents having been granted by the Government, and its Roadchef portfolio company installing electric car ultra-fast charging points across its sites along the UK motorway network. 

    • ServiceNow also confirmed its commitment to the UK market, with plans to invest £1.15 billion into its UK business over the next five years. The investment will not only support the future development of AI in the UK, expanding its data centres with Nvidia GPUs for local processing data, but also support new office space as the company significantly grows into employee base beyond its current headcount of 1,000 employees.  

    • Manchester Airports Group is investing more than £1.1 billion in London Stansted Airport to expand its existing terminal by around a third, help secure new air routes to key business and leisure destinations, boost local supply chains and create 5,000 jobs. This includes around £600 million to extend the terminal and £500 million to deliver a suite of improvements to the existing terminal building and wider airport estate. 

    • Eren Holdings confirmed a £1 billion investment in the redevelopment of Shotton Mill in Deeside, North Wales which is set to become the UK’s largest recycled paper manufacturing campus. This is expected to safeguard 147 jobs and create a further 220 when the site is fully commissioned. 

    • Network Rail and London & Continental Railways are creating a new property company which will attract additional private and public sector investment with the potential to deliver brownfield regeneration schemes across the rail estate with a value exceeding £1 billion. 

    • CoreWeave is building on its £1 billion investment announced in May and the opening of its European headquarters in London by investing a further £750 million-plus in the UK to support the demand for critical AI infrastructure. The investment in the UK is CoreWeave’s second largest investment in a country following the USA.  

    • DP World are investing up to £1 billion in their London Gateway container port operation. This new investment will fund two additional berths and a second rail terminal. Once built, the berths will add vital transport capacity and increase the resilience of UK supply chains, enabling businesses to access domestic and international markets and supporting the Government’s growth and decarbonisation missions. 

    • Holtec, a major US advanced nuclear engineering company, has confirmed a significant investment of £325 million in a new factory in South Yorkshire which will supply materials for civil and defence nuclear industries. They say this will create up to 490 direct and 280 indirect jobs annually during the construction phase and 1,200 direct engineering jobs created over 20 years. 

    • BW Group proceeding with a £500 million investment, which includes new battery energy storage projects in Hampshire and Birmingham. 

    • Eli Lilly and Company is collaborating with government through a memorandum of understanding which will see the pharmaceutical giant intending to commit £279 million to tackle significant health challenges – including obesity. Lilly also plans to launch the first ‘Lilly Gateway Labs’ innovation accelerator in Europe to support early-stage life sciences businesses to develop transformative medicines and technologies. 

    • Associated British Ports (ABP), the UK’s largest port operator, has announced a £200+ million investment in a new freight ferry terminal at the Port of Immingham, boosting the capacity and resilience of UK trade with Europe. This is expected to create around 700 jobs during construction and 200 permanent jobs once operational. 

    • Imperial College London investing £150 million to build The WestTech Corridor – a new innovation ecosystem in West London which will act as a powerful engine for investment, inclusive economic growth, and job creation at a local, regional, and national level. 

    • Haleon has received planning permission to develop a new £130 million Global Oral Health Innovation Centre in Weybridge, Surrey. This state-of-the-art facility will primarily support Haleon’s global oral health business by developing new products that advance consumers’ better everyday health. 

    Background 

    • The International Investment Summit is being sponsored by Barclays, HSBC, Lloyds, M&G plc, Octopus Energy, and TSL.

    Updates to this page

    Published 14 October 2024

    MIL OSI United Kingdom –

  • MIL-OSI Asia-Pac: Meeting held on animal deaths

    Source: Hong Kong Information Services

    ​In view of the death of eight animals in Hong Kong Zoological & Botanical Gardens yesterday, Secretary for Culture, Sports & Tourism Kevin Yeung convened an urgent interdepartmental meeting today to hear reports on the latest situation by the Leisure & Cultural Services Department, the Agriculture, Fisheries & Conservation Department as well as the Department of Health.

    It was noted at the meeting that park staff had immediately stepped up monitoring of the conditions of all animals since yesterday. The movement response and appetite of a White-faced Saki and a De Brazza’s Monkey were found to be unusual and they were removed from the original animal cages for close monitoring. The White-faced Saki passed away this morning. The park will continue to observe the remaining De Brazza’s Monkey.

    The park’s Mammals Section was temporarily closed this morning to facilitate the close monitoring of the conditions of those animals, while the disinfection and cleaning of animal cages involved were completed.

    The health condition of all 80 animals in the park is normal. For the sake of prudence, staff working there will wear appropriate protective gear and keep a close watch on their health condition. At present, all staff are healthy.

    Additionally, different scenarios of case development and solutions were discussed at the meeting. Relevant government departments will speed up autopsy and toxicological testing, so that the possible causes of the incident could be known as soon as possible.

    MIL OSI Asia Pacific News –